<![CDATA[This study aims to determine the effect of soft coral ethanol extract (Nephthea sp.) on the histopathological effect of mice (Mus musculus) lungs. Soft coral was extracted using 95% ethanol to obtain a viscous extract. Thirty mice were divided into six treatment groups in 3 replicates, the negative control group was only given standard feed, the positive control group was exposed to 37% HCl for 10 days, the preventive group 1 and 2 were given soft coral extract 0.5g and 1g respectively. orally on day 8 before being given 37% HCl for 10 days, and the curative group was given 0.5g and 1g soft coral extract, respectively, on day 19 after being given 37% HCl for 10 days. All mice were sacrificed and the lungs were taken for histopathological preparation using paraffin method and Hematoxylin-Eosin staining. Parameters observed were the alveolar membrane, the lumen of the alveolus, and the relationship between the alveoli. The results showed that there was an effect of giving soft coral ethanol extract (Nephthea sp.) to changes in the histopathological effect of mice's lungs. The preventive and curative group given 1 g of soft coral extract was more effective in reducing the level of damage to the lungs due to exposure to HCl 37%. The conclusion of this study was that the administration of soft coral extract (Nephthea sp.) had an effect on changes in the histopathological effect of the lung of mice.]]>
