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All Journal SAINSMAT: Jurnal Ilmiah Ilmu Pengetahuan Alam
A. Mu'nisa A. Mu'nisa
Universitas Negeri Makassar

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Efektivitas Ekstrak Etanol Karang Lunak (Nephthea sp.) terhadap Gambaran Histopatologi Paru-Paru Mencit (Mus musculus) A. Mu'nisa A. Mu'nisa; Andi Faridah Arsal; A. Muflihunna A. Muflihunna; Adlillah Triastuti
Sainsmat : Jurnal Ilmiah Ilmu Pengetahuan Alam Vol. 11 No. 2 (2022): Volume 11 Nomor 2 (September 2022)
Publisher : Fakultas Matematika dan Ilmu Pengetahuan Alam Universitas Negeri Makassar

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Abstract

This study aims to determine the effect of soft coral ethanol extract (Nephthea sp.) on the histopathological effect of mice (Mus musculus) lungs. Soft coral was extracted using 95% ethanol to obtain a viscous extract. Thirty mice were divided into six treatment groups in 3 replicates, the negative control group was only given standard feed, the positive control group was exposed to 37% HCl for 10 days, the preventive group 1 and 2 were given soft coral extract 0.5g and 1g respectively. orally on day 8 before being given 37% HCl for 10 days, and the curative group was given 0.5g and 1g soft coral extract, respectively, on day 19 after being given 37% HCl for 10 days. All mice were sacrificed and the lungs were taken for histopathological preparation using paraffin method and Hematoxylin-Eosin staining. Parameters observed were the alveolar membrane, the lumen of the alveolus, and the relationship between the alveoli. The results showed that there was an effect of giving soft coral ethanol extract (Nephthea sp.) to changes in the histopathological effect of mice's lungs. The preventive and curative group given 1 g of soft coral extract was more effective in reducing the level of damage to the lungs due to exposure to HCl 37%. The conclusion of this study was that the administration of soft coral extract (Nephthea sp.) had an effect on changes in the histopathological effect of the lung of mice.
Kerusakan Morfologis Paru-Paru Mencit Akibat Pemberian Asam Kuat Dengan Konsentrasi Berbeda A. Mu'nisa A. Mu'nisa; Rachmawaty Rachmawaty; Halifah Pagarra; Hilda Karim; Theodorus K. Tokan
Sainsmat : Jurnal Ilmiah Ilmu Pengetahuan Alam Vol. 11 No. 2 (2022): Volume 11 Nomor 2 (September 2022)
Publisher : Fakultas Matematika dan Ilmu Pengetahuan Alam Universitas Negeri Makassar

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Abstract

This study aims to determine the damage to lung morphology in mice (Mus musculus) by administering various strong acids by inhalation. The string acids used in this study are HCl 30%, H2SO4 50%, and HNO3 50%). The subjects of the study were 2-month old mice which were divided into 4 treatment groups consisting of 2 mice per group. There are 4 gorups of mice; a control group, a treatment group with 37% hydrochloric acid (HCl), a group with with sulfuric acid (H2SO4) 50% treatment, and a group with nitric acid (HNO3) 50% treatment. Strong acids are given simultaneously with standard feed and drinking water ad libitium. Tthe mice (Mus musculus) were euthanized 10 days post treatment and surgery was performed to observe lung morphology consisting of color, weight, and shape. The study showed that the administration of strong acid damaged the lung morphology of mice and the agent causing most severe damage of lungs was the 50% nitric acid (HNO3).
Co-Authors A. Muflihunna A. Muflihunna Adlillah Triastuti Andi Faridah Arsal Hilda Karim Pagarra, Halifah Rachmawaty, Rachmawaty Theodorus K. Tokan