<![CDATA[Abstrak Fatigue merupakan masalah yang sering dialami pasien Chronic Kidney Disease (CKD) yang menjalani hemodialisis akibat anemia, akumulasi toksin uremik, gangguan metabolisme, dan penurunan kapasitas fisik. Kondisi ini dapat mengganggu aktivitas sehari-hari sehingga memerlukan intervensi yang tepat. Penelitian ini bertujuan memaparkan penerapan asuhan keperawatan melalui kombinasi terapi relaksasi Benson dan latihan isometrik terhadap fatigue pada pasien CKD yang menjalani hemodialisis. Penelitian menggunakan desain studi kasus melalui pendekatan proses keperawatan. Subjek dipilih secara purposive sampling pada pasien Ny. E dengan CKD stadium 5 yang menjalani hemodialisis dan mengalami fatigue dengan skor awal Fatigue Severity Scale (FSS) 30. Data dikumpulkan melalui wawancara, observasi, pemeriksaan fisik, dan studi dokumentasi. Intervensi berupa relaksasi Benson selama 15–20 menit dan latihan isometrik selama 15–20 menit diberikan sebanyak empat kali pertemuan dalam dua minggu selama hemodialisis. Evaluasi dilakukan menggunakan FSS serta indikator pendukung berupa frekuensi napas, lama tidur, dan kemampuan aktivitas. Hasil menunjukkan penurunan skor fatigue dari 30 menjadi 15, disertai penurunan frekuensi napas, peningkatan lama tidur, dan kemampuan aktivitas. Kombinasi terapi ini menunjukkan hasil positif dalam membantu menurunkan fatigue dan meningkatkan kemampuan fungsional pasien CKD yang menjalani hemodialisis sehingga dapat dipertimbangkan sebagai intervensi keperawatan nonfarmakologis pendamping. Kata kunci: Chronic Kidney Disease (CKD), Fatigue, Hemodialisis, Latihan isometrik, Relaksasi Benson Abstract Fatigue is a problem that is often experienced by Chronic Kidney Disease (CKD) patients undergoing hemodialysis due to anemia, accumulation of uremic toxins, metabolic disorders, and decreased physical capacity. This condition can interfere with daily activities and therefore requires appropriate intervention. This study aims to explain the application of nursing care through a combination of Benson relaxation therapy and isometric exercises against fatigue in CKD patients undergoing hemodialysis. The research used case study design through nursing process approach. Subjects were selected by purposive sampling in patients with Ms. E with Stage 5 CKD who underwent hemodialysis and experienced fatigue with an initial Fatigue Severity Scale (FSS) score of 30. Data were collected through interviews, observations, physical examinations, and documentation studies. Interventions such as Benson relaxation for 15-20 minutes and isometric exercises for 15-20 minutes were given four meetings in two weeks during hemodialysis. Evaluation was conducted using FSS and supporting indicators such as Breath frequency, sleep duration, and activity ability. Results showed a decrease in fatigue score from 30 to 15, accompanied by a decrease in Breath frequency, increased sleep duration, and activity ability. This combination therapy shows positive results in helping to reduce fatigue and improve the functional ability of CKD patients undergoing hemodialysis so that it can be considered as a companion nonpharmacological nursing intervention. Keywords: Benson relaxation, Chronic Kidney Disease (CKD), Fatigue, Hemodialysis, Isometric exercises]]>
