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All Journal Asian Journal of Fertility, Endocrinology, and Reproduction
Ani Khoirinda
Department of Midwifery, Sekolah Tinggi Ilmu Kesehatan Maharani, Malang, East Java, Indonesia
Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Social Sciences

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Utilization of Cranberries (Vaccinium Macrocarpon) in Menopausal Women With Recurrent Urinary Tract Infections: A Systematic Review and Meta-Analysis Ani Khoirinda; Sutrisno Sutrisno
ASIAN JOURNAL OF FERTILITY ENDOCRINOLOGY AND REPRODUCTION Vol. 1 No. 1 (2026): January 2026
Publisher : Malang Reproductive Training Center

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.66060/ajfer.v1i1.4

Abstract

Introduction: Menopause is a condition in women who experience menstrual cessation for 12 months. The average age of menopausal women is 45 – 55 years. In comparison, early menopause occurs at <40 years. Hormonal changes are one of the characteristics of menopausal women, and these changes can affect the bladder organs, leading to an increase in vaginal pH > 5, which can lead to UTIs. Treatment is needed to prevent recurrent UTIs. Cranberry is one of the treatments that can be given and is included in phytopharmaceutical treatment. In addition, cranberries can be given to menopausal women who have a history of recurrent UTIs or are experiencing UTIs. Methods: A systematic review was used, including journal articles published on Google Scholar, ScienceDirect, and PubMed. The article used is original research. Statistical evaluation for meta-analysis using Review Manager (RevMan) v.5.4, Risk Ratio with a CI95% CI. Results: Four studies that met the inclusion criteria in the relationship of cranberry administration in menopausal women were compared to placebo; the total population in this study was as many as (n = 947). In the combined analysis of cranberry juice and placebo capsules, the incidence of rUTI was significantly lower in the cranberry group than in the placebo group (RR 0.71, 95% CI 0.57-0.89; p = 0.003). In addition, the incidence of rUTI was significantly lower in the cranberry group than in the placebo group (RR 0.74; 95% CI 0.56, 0.98; p = 0.03). Conclusion: In a double-blinded study, it was found that Cranberry administration has an influence on the incidence of rUTI in menopausal women. Cranberry juice obtained significant results in the treatment group compared to the placebo.
Co-Authors Sutrisno Sutrisno