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All Journal Green Medical Journal
Imran Safei
Dosen Fakultas Kedokteran Universitas Muslim Indonesia, Makassar, Indonesia
Biochemistry, Genetics & Molecular Biology Immunology & microbiology Medicine & Pharmacology Public Health

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The Role of Reactive Oxygen Species in Muscle: Beneficial/Harmful Zulfahmidah Zulfahmidah; Imran Safei
Green Medical Journal Vol 4 No 3 (2022): Green Medical Journal
Publisher : Fakultas Kedokteran Universitas Muslim Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33096/gmj.v4i3.129

Abstract

Introduction: Skeletal muscle produces moderate quantities of oxidant species, such as reactive oxygen species (ROS) and reactive nitrogen species (RNS), due to its contractile action, high oxygen consumption, and metabolic rate (RNS). Under normal physiological circumstances, the generation and removal of ROS/RNS are in dynamic equilibrium. Content: The body reaches a condition of oxidative stress, however, when the oxidation products surpass the antioxidant defense capability. Increased oxidative stress has significant ramifications for the molecular, structural, and functional integrity of muscle. The release of reactive oxygen species (ROS) under pathological circumstances leads to cellular dysfunction and the progression of muscle disorders. Conclusion: The antioxidants can put ROS in optimal concentrations to perform physiological signals in muscle. At appropriate concentrations, ROS and RNS can regulate intracellular signal transduction. Thus, moderate quantities of radicals are advantageous to muscle, but high doses of ROS are harmful. The aim of this review is to know about the role of ROS in muscle.
Co-Authors Zulfahmidah