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All Journal Jurnal Penelitian Pendidikan IPA (JPPIPA) Media Farmasi UMI Medical Journal Indian Journal of Forensic Medicine & Toxicology INDONESIAN JOURNAL OF HEALTH jpki Jurnal Farmasi Indonesia

Zulfahmidah

Departemen Biokimia, Fakultas Kedokteran, Universitas Muslim Indonesia

Author-ID : 2465157

Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Dentistry Education Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Nursing Physics Public Health Veterinary

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Simvastatin Toxicity Induces Mitochondrial Dysfunction in Rat Skeletal Muscle Zulfahmidah; Marhaen Hardjo; Syahrijuita Kadir
Indian Journal of Forensic Medicine & Toxicology Vol. 15 No. 3 (2021): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v15i3.16023

Background: Statins are the class of drugs that are widely used for lowering LDL cholesterol and as primary and secondary prevention to cardiovascular disease. However, the widespread use of statins is constrained by the presence of toxicity or intolerance, which affects drug control rates. The toxicity or intolerance of statins ranges from 10-15%. The most common statin toxicity is statin-associated muscle symptoms (SAMS). The underlying mechanisms of SAMS involve the disruption of mitochondrial biogenesis, potential membrane changes, reduced number of mitochondria, and changes in protein oxidative activity due to the accumulation of ROS in cells and tissues. The disruption of mitochondrial biogenesis can be marked by a decrease of peroxisome proliferator-activated receptor co-activator gamma (PGC-1a). This study aimed to determine the effect of simvastatin on skeletal muscle PGC-1a.Methods: Sixteen female Wistar rats (8-10 weeks of age) were randomized into 2 groups: (1) control group (n=8), and (2) simvastatin group(n=8). For 30 days, the simvastatin group was exposed to simvastatin at a dose of 10 mg/kg/day. Meanwhile, the control group animals only received 0.5% methyl cellulose. Gastrocnemius muscles were collected and PGC-1a levels were evaluated by using ELISA Kit.Results: Following 30 days of treatment, a significantly lower level of skeletal muscle PGC-1awas observed in the simvastatin group compared to the control group (p = .026). Conclusion: Our finding indicates that administration of simvastatin at a dose of 10 mg/kg/day for 30 days may decrease skeletal muscle PGC-1a leading to mitochondrial dysfunction in rat skeletal muscle

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v15i3.16293

Background: Statins are the class of drugs that are widely used for lowering LDL cholesterol and as primaryand secondary prevention to cardiovascular disease. However, the widespread use of statins is constrained bythe presence of toxicity or intolerance, which affects drug control rates. The toxicity or intolerance of statinsranges from 10-15%. The most common statin toxicity is statin-associated muscle symptoms (SAMS). Theunderlying mechanisms of SAMS involve the disruption of mitochondrial biogenesis, potential membranechanges, reduced number of mitochondria, and changes in protein oxidative activity due to the accumulationof ROS in cells and tissues. The disruption of mitochondrial biogenesis can be marked by a decrease ofperoxisome proliferator-activated receptor co-activator gamma (PGC-1a). This study aimed to determine theeffect of simvastatin on skeletal muscle PGC-1a.Methods: Sixteen female Wistar rats (8-10 weeks of age) were randomized into 2 groups: (1) control group(n=8), and (2) simvastatin group(n=8). For 30 days, the simvastatin group was exposed to simvastatinat a dose of 10 mg/kg/day. Meanwhile, the control group animals only received 0.5% methyl cellulose.Gastrocnemius muscles were collected and PGC-1a levels were evaluated by using ELISA Kit.Results: Following 30 days of treatment, a significantly lower level of skeletal muscle PGC-1awas observedin the simvastatin group compared to the control group (p = .026).Conclusion: Our finding indicates that administration of simvastatin at a dose of 10 mg/kg/day for 30 daysmay decrease skeletal muscle PGC-1a leading to mitochondrial dysfunction in rat skeletal muscle.

Perbedaan Status Gizi Penderita Tuberkulosis Paru Sebelum dan Sesudah Pengobatan Di RS Ibnu Sina Makassar Shofiyah Latief; Zulfahmidah zulfahmidah; Asrini Safitri; Edward Pandu Wiriansya; Muhamad Ilhamsyah Dandung
UMI Medical Journal Vol 6 No 1 (2021): Umi Medical Journal
Publisher : Fakultas Kedokteran Universitas Muslim Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33096/umj.v6i1.133

Latar belakang: Tercatat, angka prevalensi kejadian TBC di Indonesia pada tahun 2014 sebesar 297 per 100.000 penduduk. Pada Sulawesi Selatan yang terkonfirmasi secara bakterilogis di antara semua pasien TB paru yang tercatat atau diobati mencapai 1,234 (20.97%) Hal ini belum mencapai target yang diharapkan. Metode: Penelitian ini adalah penelitian analitik komparatif dengan metode cross sectional dengan jumlah sampel 68 orang. Analitik data menggunakan Uji t sampel berpasangan. Hasil: Jenis kelamin laki-laki lebih tinggi sebesar 64,7% (44 orang) dan perempuan 35,3%(24 orang). Sampel pada usia tertinggi yaitu usia 18-28 tahun 26,5%(18 orang). Sampel sebelum pengobatan terbanyak dengan status gizi underweight 64,7%(44 orang). Sedangkan sampel sesudah pengobatan terbanyak dengan status gizi normal 51,5%(35 orang). Berdasarkan hasil analisis statistik didapatkan perbedaan yang signifikan antara status gizi pada penderita TB paru dewasa sebelum dan sesudah pengobatan. Kesimpulan: Terdapat perbedaan yang signifikan antara status gizi pasien penderita TB paru dewasa sebelum pengobatan dan sesudah pengobatan.

EFEKTIVITAS BIAYA PENGGUNAAN ANTIBIOTIK PASIEN COVID-19 DI RUMAH SAKIT TADJUDDIN CHALID MAKASSAR Andi paluseri; Rika Oktaviani; Zulfahmidah Zulfahmidah; Fajriansyah Fajriansyah
Media Farmasi XXX Vol 17, No 1 (2021): Media Farmasi
Publisher : Jurusan Farmasi Politeknik Kesehatan Makassar, Kementerian Kesehatan RI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32382/mf.v17i1.2050

Cost-Effectiveness Analysis Of The Use Of The Antibiotics Levofloxacin And Azithromycin In Patients With Coronavirus Disease 2019Corona Virus Diseases 2019 (COVID-19) is an infectious disease caused by severe acute respiratory syndrome corona virus 2 (SAR-CoV-2) which causes respiratory infections. This disease requires a large cost in the management process. Therefore, this research aims to analyze the cost-effectiveness in the use of azithromycin and levofloxacin antibiotics in the treatment of COVID-19 at a General hospital in Makassar City. This is an observational cross-sectional research with a prospective data collection method (January-March 2021) and a total sampling technique. Furthermore, data were taken from medical records and part of the financial information system, including patients' characteristics data (medical record number, patient initials, age, gender), clinical data (diagnosis, swab-test results), drug use data (dosage, rules of use, and duration of drug administration), and total medical costs (healthcare perspective: drug, treatment, laboratory, and radiology costs). Moreover, the effectiveness of this study was measured by the number of patients that were declared cured (negative swab-test). The results showed that the ACER value of the levofloxacin and azithromycin antibiotic were Rp. 191,705 and Rp. 157,359 respectively. These results indicate that the azithromycin antibiotic therapy group is more cost-effective compared to the levofloxacin group. Keywords : Cost Effectiveness, COVID-19, Antibiotics.Corona Virus Diseases 2019 (COVID-19) merupakan penyakit menular yang disebabkan oleh severe acute respiratory syndrome corona virus 2 (SAR-CoV-2) yang dapat menyebabkan infeksi saluran pernapasan. Penyakit ini membutuhkan biaya besar dalam proses penatalaksanaannya. Penelitian ini bertujuan untuk menganalisis nilai cost-effectiveness penggunaan antibiotik azitromisin dan levofloksasin pada pengobatan COVID-19 pada salah satu Rumah Sakit Umum di Kota Makassar. Desain penelitian ini adalah observasional cross-sectional dengan pengambilan data secara prospektif (Januari-Maret 2021). Teknik pengambilan sampel pada penelitian ini adalah total sampling. Data diambil dari rekam medis pasien dan bagian sistem informasi keuangan pada salah satu Rumah Sakit Umum di Kota Makassar, meliputi data karakteristik pasien (nomor rekam medis, inisial pasien, umur, jenis kelamin), data klinis pasien (diagnosis, hasil swab-test), data penggunaan obat (dosis, aturan pakai, dan lama pemberian obat), data total biaya pengobatan (healthcare perspective: biaya obat, biaya perawatan, biaya laboratorium, biaya radiologi). Efektivitas dalam penelitian ini diukur dari jumlah pasien yang dinyatakan sembuh (hasil pemeriksaan swab-test dinyatakan negatif). Hasil penelitian menunjukan nilai ACER antibiotik levofloksasin sebesar Rp. 191.705 dan nilai ACER antibiotik azitromisin sebesar Rp. 157.359. Hasil ini menunjukan bahwa kelompok terapi antibiotik azitromisin lebih cos-effective dibandingkan dengan kelompok terapi antibiotik levofloksasin. Kata Kunci : Efektivitas Biaya, COVID-19, Antibiotik

Profil Mikrobiota Saluran Cerna Pada Anak, Dewasa, Berbagai Suku dan Ras Dzulfachri Kurniawan; Armanto Makmun; Zulfahmidah Zulfahmidah; Windy Nurul Aisyah
Indonesian Journal of Health Vol 1 No 01 (2020): Vol.01 No.01 (Oktober 2020)
Publisher : Yayasan Citra Cendekia Celebes

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (226.634 KB)

Background and Purpose: Microbiota is defined as a collection of microorganisms that live in the host's body, which can consist of bacteria, archae, viruses, and other eukaryotes. Microbiota in humans is also found in the skin, lungs, urinary tract, oral cavity, although the digestive tract plays a role in contributing to the highest number of microbiota in humans. The purpose of this article is to provide an overview of the various profiles of the gastrointestinal microbiota in children, adults, various ethnicities and races. Methods: This study uses a narrative review method. The data sources of this study come from literature obtained via the internet in the form of research results from national and international journals in 2010-2020 such as Elsevier, Clinical Key, Pubmed, Biomed Research International, Nature Journal, PLOS Computational Biology, PNAS Journal dan American Society For Microbiology. Results: From several collections of journals related to microbiota, many studies reveal that the two bacterial phyla Firmicutes and Bacteroidetes are found in a higher proportion in humans in general followed by Prevotella, Actinobacteria and Bifidobacterium. Whereas in children the microbiota is more dominated by Bacteroidetes / Bifidobacterium and not a few studies have found Clostridium in children. It is no different from ethnicities and races from other countries in that the findings of general microbiota are almost the same. Various microbiota also can be built from the environment, geography, ethnicity and culture. Conclusion: The variability of the microbiota in the human tract is very diverse, it is related to various factors, namely age, genetics, metabolic, diet, diet, lifestyle, environment, geography, ethnicity, culture and socio-economy.

Peran Status Gizi Terhadap Tingkat Kecerdasan Kognitif Anak Mufia Muin; Nurfardiansyah Burhanuddin; Zulfahmidah Zulfahmidah; Windy Nurul Aisyah Aisyah
Indonesian Journal of Health Vol 1 No 01 (2020): Vol.01 No.01 (Oktober 2020)
Publisher : Yayasan Citra Cendekia Celebes

Background and Objectives: Nutritional status is important role in the metabolism of the body and in the process of thinking or reasoning a role in thinking processes, concentration power and related to learning efficiency. With good nutritional condition is expected to have an impact on good learning achievement. Methods: The source of this research data comes from the literature obtained through the internet is the result of research from national or international journals in 2010-2020. Results: There are studies that explain malnutrition or obesity impact on a child's cognitive delay and good nutritional status will have an impact on the cognitive improvement of the child. But optimal cognitive development is not enough just with good nutritional status, it takes good stimulus efforts. Conclusion: Nutritional status is important for cognitive development in children.

Peran Mikrobiota Usus Terhadap kondisi Obesitas Armanto Makmun; Wialda Dwi Rodya; Zulfahmidah Zulfahmidah; Windy Nurul Aisyah Aisyah
Indonesian Journal of Health Vol 1 No 01 (2020): Vol.01 No.01 (Oktober 2020)
Publisher : Yayasan Citra Cendekia Celebes

The gut microbiota has been recognized as an important factor in the development of metabolic diseases such as obesity and is considered an endocrine organ involved in the maintenance of energy homeostasis and immunity. Intestinal dysbiosis can alter gastrointestinal peptide production associated with satiety, resulting in increased food intake. In obese people, this dysbiosis appears to be associated with increased gut microbiota has been implicated in the control of food intake and satiety via intestinal peptide signaling, in which bacterial products activate enteroen-docrine cells by modulating enterocyte-produced paracrine signaling molecules. The gut microbiota can increase the production of certain SCFAs, which have been shown to be associated with increased production of YY (PYY) peptides, ghrelin, insulin, and glucagon-like peptide-1 (GLP-1). The purpose of this study was to Article Review by looking at the topic of the gut microbiota and obesity by using research with quantitative meta-analysis methods based on previous research. This research method uses the article review method. The data source of this research comes from literature obtained via the internet in the form of research results from international journals in 2010-2020. The results of this study from a total of 50 journals, which the authors have reviewed, concluded that the role of the gut microbiota in energy regulation, studies have linked the gut microbiota with the pathogenesis of insulin resistance and inflammation in obesity. It is known that obesity is associated with low-grade chronic inflammation and insulin resistance. The gut microbiota has been implicated in the control of food intake and satiety through intestinal peptide signaling, in which bacterial products activate enteroen-docrine cells by modulating the enterocyte-produced paracrine signaling molecules. The conclusion of this study based on the results of the study found that the effect of intestinal microbiotas on obesity.

Efektifitas Kurma Ajwa dalam berbagai Penyakit Zulfahmidah Zulfahmidah; Risna Sri Wahyuni. M; Afrina F.Bustan
Indonesian Journal of Health Vol 2 No 01 (2021): Vol.02 No.01 (Oktober 2021)
Publisher : Yayasan Citra Cendekia Celebes

The incidence of disease increases due to improper eating patterns, irregular eating patterns, consumption of processed foods except for the fruits of the food consumed. According to WHO statistics on diabetes mellitus, heart disease and ischemic stroke are the leading causes of death globally. Fruits are highly recommended by WHO to improve public health and public welfare. In building the health and well-being awareness of the past two decades significant progress has been made in the study of bioactive compounds in dates to find their immediate effects on human health. Dates Ajwa (Phoenix dactylifera L.) is a fruit that grows in many Arab countries, especially the city of Medina, Saudi Arabia. Based on several studies, dates have various phytochemical contents such as kumarat acid, ferric acid, flavonoids, phenolics, sterols, procyanidins, anthocyanins, carotenoids, vitamins and minerals that function as antioxidants, antihyperlipidimics, hepatoprotective, antimutagenic, antiinflammatory, nephroprotective and many other benefits in protecting the body from various diseases. Ajwa dates contain a high percentage of carbohydrate fiber (44-88%), dietary fiber (6.4-11.5%), fat (0.2-0.5%), protein (2.3-5.6 %), minerals and vitamins; also contains several fatty acids including palmic, oleic, linoleic and linolenic acids. Based on the description above, the researcher is interested in further studying the benefits contained in the Ajwa Dates.

Hubungan Status Sosial Ekonomi dengan Indeks Massa Tubuh (IMT) di Kecamatan Tamalanrea Kota Makassar Meilinda Aji Syahputri; Zulfahmidah Zulfahmidah; Windy Nurul Aisyah
Indonesian Journal of Health Vol 1 No 02 (2021): Vol.01 No.02 (Februari 2021)
Publisher : Yayasan Citra Cendekia Celebes

Background: Nutrition is a factor that plays an important role in the development of a nation. One simple waythat can be used to determine nutritional status is to measure the Body Mass Index (BMI) or Body Mass Index(BMI). One of the factors that play a role in determining a person's nutritional status is the socioeconomic level.The socio-economic level includes education, income, and work which are indirect causes of nutritionalproblems. Efforts to improve good health are related to economic capacity with income levels and socialconditions of household members. How economics plays a role in the health record of each individual. Thepurpose of this study was to see the status of the socio-economic relationship with the Body Mass Index (BMI).Methods: This study is a descriptive research design. Data collected using a questionnaire. The data of thisstudy were categorical variables from 2 groups so that it used the Chi-Square test. Results: From 84 samples,based on the calculation of IBM SPSS Statistic 23 using the Chi-Square analysis test, it was obtained that the P-value (0.125) ≥ 0.05, then H0 was accepted and Ha was rejected, meaning that there was no influence of BMIinfluence on socio-economic factors. Conclusion: There is no relationship between socioeconomic status andBody Mass Index (BMI).

Tingkat Kepuasan Pasien Rawat Jalan Terhadap Mutu Pelayanan Kesehatan di Puskesmas Sendana Zulfahmidah Zulfahmidah; Resky Asfiani Rahman
Indonesian Journal of Health Vol 2 No 01 (2021): Vol.02 No.01 (Oktober 2021)
Publisher : Yayasan Citra Cendekia Celebes

Background and Objectives: Patient satisfaction is an indicator indicator of providing health services to the community. One of the development efforts in the health sector is the availability of quality health services such as the existence of a health center. Puskesmas must have good quality health services that can be seen from the performance or the perceived benefits, in order to give satisfaction to patients. The purpose of this study was to see the level of outpatient satisfaction with health services, so that it can be used as evaluation material for the health center. Methods: This study used a quantitative descriptive research method with a cross-sectional study design. The research variables included the quality of health services which consisted of aspects of reliability, responsiveness, empathy, facilities, and assurance. The population in this study were patients who visited the Sendana Health Center. The sampling technique was accidental sampling and obtained 31 respondents. Results: The results of the study the patient scores were analyzed and grouped according to their level in order to obtain a satisfaction level of 70.4% reliability aspects, 67.5% responsiveness, 66.9% empathy, 57.7% facilities, and 65.3% assurance. Conclusion: Overall satisfaction level is included in the satisfied category.

Co-Authors Afrina F.Bustan Agung Dirgantara Andi paluseri Andi Sitti Fahirah Andry Pratama Anna Sari Dewi Annisa Tri Srilistiany Arina Fathiyyah Armanto Makmun Arni Isnaini Arfah Asrini Safitri Asrini Safitri Awaluddin, Akbar Dahlia Dahlia Dian Amelia Abdi Dzulfachri Kurniawan Eny Arlini Wello Erlin Syahril Fajriansyah Fajriansyah Febie Irsandy Fendy Dwimartyono Imran Safei Imran Safei, Imran Kasmawati Kasmawati Lisa Yuniaty M. Hamsah Marhaen Hardjo Marhaen Hardjo Meilinda Aji Syahputri Mufia Muin Muhamad Ilhamsyah Dandung Muhammad Mursyid Nasrudin Andi Mappaware Nurelly Noro Waspodo Nurfardiansyah Burhanuddin Rahmawati Rahmawati Rasfayanah Rasfayanah Resky Asfiani Rahman Rezky Putri Indarwati Abdullah Rika Oktaviani Risna Sri Wahyuni. M Santriani Hadi Shofiyah Latief Sri Wahyu Sri Wahyuni Gayatri Surya Sumantri Abdullah Syahrijuita Kadir Syamsu Rijal Welly Wialda Dwi Rodya Windy Nurul Aisyah Windy Nurul Aisyah Windy Nurul Aisyah Aisyah Wiriansya, Edward Pandu Yusriani Mangarengi Zulfitriani Murfat Zulfiyah Surdam

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