Background: As primary health care facilities, Community Health Centers (Puskesmas) require human resources with optimal performance and high levels of job satisfaction. Employee performance is influenced by various factors, including leadership characteristics, work environment, salary, and length of service. This study aimed to examine the effects of leadership characteristics, work environment, salary, and length of service on job satisfaction and employee performance at Puskesmas. Subjects and Method: This quantitative study employed a cross-sectional design and involved 170 civil servant employees selected through proportional random sampling. Data were collected using a structured questionnaire and analyzed using path analysis. Results: The findings revealed significant indirect effects of leadership characteristics (b = 0.47; 95% CI = 0.36 to 0.59; p < 0.001), work environment (b = 0.49; 95% CI = 0.38 to 0.59; p < 0.001), and salary (b = 0.15; 95% CI = 0.04 to 0.25; p = 0.005) on employee performance through job satisfaction. Length of service had a significant indirect effect on job satisfaction and employee performance through salary (b = 0.36; 95% CI = 0.24 to 0.48; p < 0.001). In addition, job satisfaction had a direct and statistically significant effect on employee performance at Puskesmas (b = 0.37; 95% CI = 0.26 to 0.48; p < 0.001). Conclusion: Leadership characteristics, work environment, salary, and length of service play important roles in shaping job satisfaction and employee performance at Puskesmas. Leadership, work environment, and salary enhance employee performance indirectly through job satisfaction. Length of service does not have a direct effect on performance but influences it indirectly through salary. Furthermore, job satisfaction has a direct and significant impact on employee performance.