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Reni Paramita
Departement of Biochemistry and Molecular Biology, Faculty of Medicine, University of Indonesia, Jakarta 10430 / Doctoral Program in Biomedical Sciences, Faculty of Medicine, University of Indonesia, Jakarta 10430
Dentistry Health Professions Medicine & Pharmacology Nursing Public Health

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Journal : Medical Journal of Indonesia

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Effect of hypoxia-inducible factor-1α induction by CoCl2 on breast cancer cells survival: influence of cytochrome-c and survivin Paramita, Reni; Sadikin, Mohamad; Sutandyo, Noorwati; Wanandi, Septelia I.
Medical Journal of Indonesia Vol 23, No 3 (2014): August
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (596.052 KB) | DOI: 10.13181/mji.v23i3.933

Abstract

Background: Tumor tissue usually became hypoxic due to disruption of oxygen supply. Adaptation response to hypoxia is mediated by transcription factor, hypoxia- inducible factor-1α (HIF-1α). HIF-1α signaling is known to increase the expression of pro-apoptotic protein cytochrome-c, and anti- apoptotic survivin. In this study we wanted to analyze the role of HIF-1α on breast cancer cells survival through pro-apoptosis cytohrome-c and anti-apoptosis survivin regulation.Methods: Breast cancer cell lines T47D were induced by CoCl2 then harvested to analyze the expression of HIF-1α, protein cytochrome-c, mRNA survivin and cell viabilities.Results: HIF-1α induction by CoCl2 causes the increase of  protein and mRNA of HIF-1α, cytochrome-c protein, and survivin mRNA, but does not cause the changes in cell viability.Conclusion: HIF-1α induction have no effects on breast cancer cell line T47D viabilities due to the balance regulation between pro-apoptosis expression cytochrome-c and anti-apoptosis survivin.
Co-Authors Ay Ly Margareth Elisna Syahruddin Mohamad Sadikin Noorwati Sutandyo Novi Silvia Hardiany Septelia I. Wanandi SEPTELIA INAWATI WANANDI Sucitra Sucitra Syarifah Dewi