<![CDATA[Background: Hypertension and diabetes mellitus are two common degenerative diseases that increase the risk of cardiovascular complications. Rational use of antihypertensive medications can achieve successful therapy. Purpose: To determine the relationship between the appropriate use of antihypertensive drugs and the success of therapy in respondents with hypertension accompanied by diabetes mellitus. Method: Using a descriptive observational cross-sectional design, where data were collected retrospectively through patient medical records. The study was conducted at Qadr Hospital from July to December 2024. The sample consisted of 101 patients who met the inclusion criteria. Data were analyzed anivariately and bivariately using the chi-square test. Results: The characteristics are dominated by women (63.4%), age 45-59 (60.4%), and housewives (43.6%). The profile of antihypertensive drug use is mostly a combination of two drugs (47.5%), and single therapy (26.7%). Evaluation of the rationality of drug use shows that the indication is correct (100.0%), the dose is correct (100.0%), the drug is correct (98.0%), and the patient is correct (91.1%). The results of the chi-square analysis obtained a value (p-value = 0.000). Conclusion: There is a relationship between the accuracy of drug use and the success of therapy in hypertensive patients accompanied by diabetes mellitus. Keywords: Antihypertensive Drugs; Diabetes Mellitus; Hypertension; Rationality,Therapy Success. Pendahuluan: Hipertensi dan diabetes melitus merupakan dua penyakit degeneratif yang sering terjadi dan meningkatkan risiko komplikasi kardiovaskular. Penggunaan obat antihipertensi secara rasional dapat mencapai keberhasilan terapi. Tujuan: Untuk mengetahui hubungan antara ketepatan penggunaan obat antihipertensi dengan keberhasilan terapi pada responden hipertensi disertai diabetes melitus. Metode: Menggunakan observasional deskriptif dengan desain potong lintang (cross-sectional), Dimana data dikumpulkan secara retrospektif melaui rekam medis pasien. Penelitian dilaksanakan di Rumah Sakit Qadr periode Juli - Desember 2024. Sampel terdiri dari 101 responden yang memenuhi kriteria inklusi. Data dianalisis secara anivariat dan bivariat dengan uji chi-square. Hasil: Menunjukkan bahwa karakteristik didominasi oleh Perempuan (63.4%), usia 45-59 (60.4%), dan pekerjaan IRT (43.6%). Profil penggunaan obat antihipertensi terbanyak dengan kombinasi dua obat (47.5%). Dan terapi Tunggal (26.7%). Evaluasi rasionalitas penggunaan obat menunjukkan tepat indikasi (100%), tepat dosis (100%), tepat obat (98.0%), tepat pasien (91.1%). Hasil analisis chi-square didapat nilai (p-value = 0.000). Simpulan: Terdapat hubungan antara ketepatan penggunaan obat dengan keberhasilan terapi pada pasien hipertensi disertai dengan diabetes melitus. Kata kunci: Diabetes Melitus; Hipertensi; Keberhasilan Terapi; Obat Antihipertensi; Rasionalitas.]]>
