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All Journal JOURNAL OF Pharmacy and Tropical Issues
Hasti Primadilla Krismaningrum
Poltekkes Kemenkes Tanjung Karang
Medicine & Pharmacology

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Ekspresi protein pada pasien tuberkulosis kanker jaringan kelenjar getah bening dan non kelenjar getah bening Lendawati Lendawati; Hasti Primadilla Krismaningrum
JOURNAL OF Pharmacy and Tropical Issues Vol. 6 No. 2 (2026): June Edition 2026
Publisher : Indonesian Public Health-Observer Information Forum (IPHORR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56922/pti.v6i2.3681

Abstract

Background: Mycobacterium tuberculosis in patients with tuberculosis has mechanisms that induce tumor formation and contribute to the development of cancer. In more than 80% of cases, TB primarily affects the lungs and other tissues, leading to chronic inflammation. Inflammation has long been associated with the development of cancer. T lymphocytes from patients with active tuberculosis secrete high levels of vascular endothelial growth factor (VEGF). VEGF is also secreted by CD4+ T lymphocytes treated with purified tuberculin protein derivative (PPD). Purpose: To determine protein expression in tuberculosis patients with lymph node and non-lymph node TB tissue. Method: This experimental study employed immunohistochemistry. Data were analyzed using one-way ANOVA followed by the Tukey HSD test. Research data were statistically analyzed using the Mann–Whitney test. Results: Non-lymph node tuberculosis exhibits a lower cellular immune response, with the H-score method providing an accurate quantitative assessment of CD4 expression. Conclusion: CD4 protein expression based on H-score was significantly higher in lymph node tuberculosis. Suggestion: Further research correlating CD4 expression with other specific immune biomarkers is needed to clarify the immune response profile in tuberculosis.   Keywords: CD4; Immunohistochemistry; Lymph Node; Tissue; Tuberculosis.
Co-Authors Lendawati Lendawati