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All Journal Termometer: Jurnal Ilmiah Ilmu Kesehatan Dan Kedokteran International Journal of Health Science
Dian Pritasari Jeger
Universitas Udayana
Dentistry Health Professions Public Health Social Sciences

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Psilocybin in the Management of Psychological Distress and Somatic Symptoms in Palliative Care Patients I Gusti Agung Dwi Putri Anjani; Dian Pritasari Jeger
Termometer: Jurnal Ilmiah Ilmu Kesehatan dan Kedokteran Vol. 4 No. 4 (2026): Oktober: Termometer: Jurnal Ilmiah Ilmu Kesehatan dan Kedokteran
Publisher : Lembaga Pengembangan Kinerja Dosen

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55606/termometer.v4i4.6864

Abstract

Psychological and existential distress are common in palliative care and often inadequately managed by conventional therapies. This literature review aimed to evaluate current evidence on psilocybin-assisted therapy as an adjunctive intervention for patients with life-limiting illness. We hypothesized that psilocybin may reduce psychological distress and indirectly alleviate somatic symptom burden. A structured review of recent randomized controlled trials and observational studies was conducted, focusing on depression, anxiety, existential distress, and quality of life outcomes. Findings indicate that, when administered in controlled clinical settings with structured psychological support, psilocybin produces rapid and sustained reductions in depression and anxiety, particularly in advanced cancer. It also facilitates meaningful psychological experiences associated with improved spiritual well-being, reduced fear of death, and greater illness acceptance. Although not a conventional analgesic, improvements in psychological domains may lessen subjective pain and fatigue. Psilocybin represents a promising multidimensional adjunct in palliative care, warranting further large-scale investigation.
Impact of Psychological Stress on Immunity in Chronic Infections (HIV and TB): A Literature Review Made Lady Adelaida Purwanta; Dian Pritasari Jeger; Made Edwin Sridana
International Journal Of Health Science Vol. 6 No. 2 (2026): July: International Journal of Health
Publisher : Lembaga Pengembangan Kinerja Dosen

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55606/ijhs.v6i2.6980

Abstract

Human immunodeficiency virus (HIV) infection and tuberculosis (TB) remain major global health challenges, affecting not only morbidity and mortality but also patients’ quality of life and everyday functioning. In both chronic infections, psychological stress and common mental disorders—particularly depression and anxiety—often coexist and are strongly shaped by social determinants. These psychological conditions may, in turn, influence immune function and contribute to poorer clinical outcomes. This literature review explores the relationship between psychological stress, mental disorders, and immune alterations through a psychoneuroimmunology perspective. The review highlights how chronic stress activates the hypothalamic–pituitary–adrenal (HPA) axis and the sympathetic nervous system, increasing cortisol and catecholamines and forming a neuroendocrine–immune network that may suppress cellular immunity when stress is persistent. The findings support the importance of integrating medical care with psychological and social interventions to improve long-term outcomes among people living with HIV and TB.
Co-Authors I Gusti Agung Dwi Putri Anjani Made Edwin Sridana Made Lady Adelaida Purwanta