Breast cancer is the most prevalent cancer among Indonesian women and a leading cause of death. Despite national campaigns, awareness and early detection practices remain low due to limited literacy and cultural barriers. This study aimed to evaluate the effectiveness of the SADARI SHIFA (Spiritual Health Integrated for Awareness) model in improving breast cancer awareness, integrating spiritual motivation, and empowering Women through Family Empowerment and Welfare/Pemberdayaan dan Kesejahteraan Keluarga (PKK) and Women Farmer Groups/ Kelompok Wanita Tani (KWT) in Pringsewu Regency, Indonesia. This mixed method community based participatory study involved 75 participants: 50 PKK cadres and 25 KWT members. Quantitative data were collected using pre–post knowledge tests and observation of SADARI practice. Qualitative data were obtained from semi structured interviews with 10 purposively selected participants to explore perceptions and experiences regarding the spiritualhealth integration. Quantitatively, knowledge scores increased from 54.0 to 84.1 (+30.1%), and 82% of participants could correctly perform all SADARI steps. Qualitatively, thematic analysis identified three dominant themes: (1) spiritual awareness as a motivator for selfcare, (2) enhanced emotional comfort through prayer and reflection, and (3) empowerment through community solidarity. Participants expressed reduced fear and increased responsibility to maintain health as a religious duty. The SADARI-SHIFA model effectively combines medical education, spirituality, and community participation to promote early breast cancer detection. The integration of qualitative insight strengthens understanding of its psychosocial impact and supports its scalability as a culturally appropriate innovation in women’s health promotion.