<![CDATA[Background Hypertension is one of the major chronic diseases that remains a primary health issue in society. One crucial factor influencing the success of hypertension management is the patient's level of knowledge about the disease and adherence to prescribed medication. Non-adherence to treatment often leads to serious complications such as stroke, heart failure, and chronic kidney disease.The purpose of this study was to determine the relationship between knowledge levels and medication adherence among hypertensive patients at Kedi Health Center. This study employed a descriptive analytic design with a cross-sectional approach. The population included all hypertensive patients visiting Kedi Health Center between March and June 2025, totaling 55 respondents. Sampling was conducted using a total sampling technique. The research instrument was a questionnaire that had been tested for validity and reliability, covering knowledge about hypertension and medication adherence. The results showed that most respondents were aged 46–60 years (54.5%), female (67.3%), and had a secondary education level (high school, 45.5%). Good knowledge levels were recorded in 60% of respondents, adequate in 27.3%, and poor in 12.7%. High adherence was recorded in 58.2% of respondents, moderate in 27.3%, and low in 14.5%. The Chi-Square test indicated a significant relationship between knowledge and adherence (p = 0.012, p < 0.05), with patients having good knowledge tending to be more adherent. The discussion of these results aligns with previous research by Bismantara et al. (2022), which showed that patients with good knowledge have 3.2 times greater odds of adherence. Based on the Health Belief Model, perceptions of the risk of hypertension complications encourage adherence. Other factors such as family support and health education also play a role. Study limitations include a small sample size, necessitating further research. Practical implications include enhancing counseling at health centers for better blood pressure control. The study concludes that there is a significant relationship between knowledge levels and medication adherence among hypertensive patients. Increasing knowledge through regular health education can improve adherence and aid in blood pressure management for hypertensive patients]]>
