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All Journal Jurnal Biologi dan Pembelajarannya (JBP)
RINI FAUZIAH
Universitas Pendidikan Indoensia
Agriculture, Biological Sciences & Forestry Education Health Professions Immunology & microbiology

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Modifikasi Permukaan Lipid Nanopartikel Berbasis Tanaman Untuk Terapi Kanker Dan Inflamasi: Tinjauan Naratif Terstuktur RINI FAUZIAH; Diah Kusumawaty
Jurnal Biologi dan Pembelajarannya (JB&P) Vol 13 No 2 (2026): OKTOBER 2026
Publisher : Universitas Nusantara PGRI Kediri

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29407/jbp.v13i2.29115

Abstract

Plant-derived lipid nanoparticles (PDLNPs) have been widely developed as nanomedicine platforms for cancer and inflammatory therapies due to their high biocompatibility, good stability, and specific targeting ability. This study aimed to analyze the effect of surface modification on the physicochemical characteristics, cellular uptake, and therapeutic effectiveness of PDLNPs through the Structured Narrative Review approach. The results showed that unmodified PDLNPs generally exhibited exosome-like spherical morphology, stable particle size, and negative zeta potential that supported colloidal stability. Surface modification using TPGS-RNP and iRGD was proven to improve encapsulation efficiency, mucosal penetration, target tissue retention, and cellular uptake through receptor-mediated endocytosis mechanisms. In addition, natural lipids such as MGDG and plant bioactive compounds also played important roles in targeting and inducing apoptosis in cancer cells. Overall, surface modification enhanced the anticancer and anti-inflammatory effectiveness of PDLNPs, indicating their potential as a more effective and specific plant-based drug delivery system.
Co-Authors Diah - Kusumawaty