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All Journal The Journal General Health and Pharmaceutical Sciences Research
Herlina
Sekolah Tinggi Kesehatan Al-Fatah Bengkulu
Health Professions Nursing Other

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Penetapan Kadar Asam Retinoat pada Krim Antijerawat yang Beredar di Kota Bengkulu dengan Spektrofotometri UV-Vis Egi Silviana; Elly Mulyani; Dede Handika; Herlina
The Journal General Health and Pharmaceutical Sciences Research Vol. 4 No. 3 (2026): The Journal General Health and Pharmaceutical Sciences Research
Publisher : LPPM STIKES KESETIAKAWANAN SOSIAL INDONESIA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.57213/tjghpsr.v4i3.1213

Abstract

Anti-acne creams are among the cosmetics widely used by the public. However, some products are suspected to contain retinoic acid, whose use must be supervised because it can cause side effects if not used according to regulations. This study aimed to identify retinoic acid content in anti-acne creams circulating in Bengkulu City, determine its levels using UV-Vis spectrophotometry, and evaluate product safety based on the obtained levels. The study was conducted on five anti-acne cream samples obtained from beauty clinics in Bengkulu City. Qualitative identification was performed using a color reaction test with antimony trichloride (SbCl₃) reagent and thin-layer chromatography (TLC). Positive samples were then quantitatively analyzed using UV-Vis spectrophotometry at a wavelength of 342 nm. The results showed that three samples (A, D, and E) were positive for retinoic acid. The retinoic acid levels in samples A, D, and E were 0.285%, 0.105%, and 0.078%, respectively. Based on the Indonesian National Formulary, only sample E met the permitted range of 0.05–0.10%, whereas samples A and D exceeded the permitted limit. These findings indicate that anti-acne creams containing retinoic acid at levels inconsistent with regulations are still circulating.
Co-Authors Dede Handika Egi Silviana Mulyani, Elly