Introduction: Adolescence is a transitional stage from childhood to adulthood characterized by rapid physical, psychological, and reproductive development. One of the major physiological changes experienced by adolescent girls during puberty is menstruation, which is frequently accompanied by primary dysmenorrhea. Dysmenorrhea is one of the most common gynecological complaints among adolescents and may negatively affect daily activities, school attendance, academic performance, and quality of life. Acupressure has been recognized as a complementary non-pharmacological intervention for pain management. Stimulation of the Sanyinjiao (SP6) acupoint is believed to improve blood circulation and restore the balance of the spleen, liver, and kidney meridians, whereas stimulation of the Hegu (LI4) acupoint promotes the release of endogenous endorphins that help reduce pain perception. This study aimed to determine the effect of SP6 and LI4 acupressure on dysmenorrhea among seventh-grade adolescent girls at SMPN 1 Sukawati. Method: This study employed a quantitative quasi-experimental design using a non-equivalent control group approach. A total of 66 adolescent girls were recruited through purposive sampling. Data on menstrual pain intensity were collected before and after the intervention and analyzed using the Wilcoxon Signed-Rank Test. Result: The results demonstrated a statistically significant reduction in dysmenorrhea intensity following the administration of SP6 and LI4 acupressure (p < 0.05). These findings indicate that acupressure applied to the SP6 and LI4 acupoints is effective in alleviating menstrual pain among adolescent girls. In conclusion, SP6 and LI4 acupressure significantly reduced the intensity of dysmenorrhea among seventh-grade adolescent girls at SMPN 1 Sukawati. Conclusion: There is an Effect of Acupressure SP6 and LI4 on Dysmenorrhea in Grade VII Adolescent Girls at SMPN I Sukawati.