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All Journal Syifa' MEDIKA: Jurnal Kedokteran dan Kesehatan
Sigit Dwi Pramono
Departemen Biokimia, Fakultas Kedokteran, Universitas Muslim Indonesia, Rumah Sakit "IBNU SINA" YW-UMI, Makassar, Sulawesi Selatan, 90231, Indonesia
Biochemistry, Genetics & Molecular Biology Immunology & microbiology Medicine & Pharmacology Public Health

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Analysis Of Factors Influencing Compliance With The Implementation Of The Surgical Safety Checklist In The Operating Room Febriyanti Muhammad; Muhammad Wirawan Harahap; Sigit Dwi Pramono; Faisal Sommeng; Muhammad Alim Jaya
Syifa'Medika Vol 17, No 1 (2026): Syifa Medika : Jurnal Kedokteran dan Kesehatan
Publisher : Faculty of Medicine

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32502/sm.v17i1.10948

Abstract

The Surgical Safety Checklist (SSC) is a patient safety instrument used to enhance communication, coordination, and procedural consistency in surgical care. This study aimed to analyze the relationship between compliance with SSC implementation and the following factors: individual characteristics, human resources and work environment, organizational and management support, facilities and infrastructure, and team leadership. The study was conducted in the Operating Room of Ibnu Sina YW-UMI Hospital, Makassar. An analytical study design with a cross-sectional approach was employed, involving 30 respondents—comprising surgeons, anesthesiologists, and operating room nurses—selected via stratified random sampling. Data were collected using Likert-scale questionnaires and direct observation. Bivariate analysis was performed using Fisher’s Exact Test. Significant relationships were found between SSC implementation compliance and individual factors (p=0.006), human resources and work environment (p=0.029), organizational and management support (p=0.007), facilities and infrastructure (p=0.010), and team leadership (p=0.031). The proportions of compliance within the groups meeting the respective criteria were 88.0%, 63.2%, 56.3%, 58.8%, and 84.6%, respectively. In conclusion, all five factors were significantly associated with compliance in SSC implementation. However, inconsistent relationship patterns observed for some factors require cautious interpretation and further investigation.
The Effect Of Secang Wood Extract (Caesalpinia sappan L.) On Blood Glucose Levels Of Mice Induced By Alloxan Sri Wahyuni Igirisa; Andi Sitti Fahirah Arsal; Sigit Dwi Pramono; Sri Wahyuni Gayatri; Marzelina Karim
Syifa'Medika Vol 17, No 1 (2026): Syifa Medika : Jurnal Kedokteran dan Kesehatan
Publisher : Faculty of Medicine

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32502/sm.v17i1.10981

Abstract

Diabetes mellitus is a metabolic disease with increasing global prevalence, necessitating the exploration of alternative therapeutic agents from natural sources such as secang wood (Caesalpinia sappan L.). This study aimed to determine the effect of secang wood extract on blood glucose levels of alloxan-induced mice and compare its effectiveness with metformin. A true experimental study with pretest-posttest control group design was conducted on 24 male mice divided into 4 groups: negative control (distilled water), extract dose 75 mg/kgBW, extract dose 150 mg/kgBW, and positive control (metformin 100 mg/kgBW). Diabetes was induced by alloxan 120 mg/kgBW intraperitoneally. Blood glucose measurements were performed at pretest, post-induction, day 7, and day 14. The results showed that alloxan induction successfully increased blood glucose levels in all groups (263.00–296.50 mg/dL). Phytochemical tests confirmed the presence of flavonoids, tannins, alkaloids, saponins, and triterpenoids in secang wood extract. On day 14, the 150 mg/kgBW extract group showed a decrease in blood glucose levels to 137.17 ± 7.39 mg/dL, which was statistically equivalent to metformin (137.00 ± 7.38 mg/dL) and significantly different from the negative control (301.00 ± 17.18 mg/dL) (p<0.05). This effectiveness is attributed to the synergistic action of bioactive compounds, especially brazilin which has a similar mechanism to metformin in inhibiting hepatic gluconeogenesis. It can be concluded that secang wood extract at a dose of 150 mg/kgBW effectively reduces blood glucose levels with potential equivalent to metformin, making it a promising candidate for development as a safe and accessible alternative diabetes therapy from natural sources.
Co-Authors Andi Sitti Fahirah Arsal Faisal Sommeng Febriyanti Muhammad Marzelina Karim Muhammad Alim Jaya Muhammad Wirawan Harahap Sri Wahyuni Gayatri Sri Wahyuni Igirisa