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All Journal MEDICA (International Medical Scientific Journal)
Hasnawatty Surya Porouw
Poltekkes Kemenkes Gorontalo, Gorontalo, Gorontalo, Indonesia
Chemistry Dentistry Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health Veterinary

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Effectiveness of Loranthus sp. Liquid Soap in Improving Skin Moisture among Pregnant Women with Gestational Diabetes Mellitus Siti Choirul Dwi Astuti; Nancy Oiii; Hasnawatty Surya Porouw; Dicki Bakhtiar Purkon; Ayu Nala El Muna Haerussana
MEDICA (International Medical Scientific Journal) Vol. 8 No. 8 (2026): MEDICA (International Medical Scientific Journal)
Publisher : Borneo Scientific Publishing

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53770/medica.v8i8.1266

Abstract

Gestational diabetes mellitus frequently causes skin dryness due to impaired microcirculation, peripheral neuropathy, and reduced sweat gland function, increasing the risk of skin infection and decreasing maternal quality of life. Natural topical products containing bioactive compounds may provide a safe alternative for improving skin hydration during pregnancy. This study aimed to determine the most effective concentration of Loranthus sp. liquid soap for improving skin moisture in pregnant women with gestational diabetes mellitus. A quasi-experimental study using a nonequivalent control group design was conducted at the Tilango Community Health Center, Gorontalo Regency, Indonesia. Thirty pregnant women with gestational diabetes mellitus were allocated into three intervention groups receiving Loranthus sp. liquid soap containing 5%, 10%, or 15% extract (n=10 per group). Participants used 500 mL of the assigned soap twice daily for seven consecutive days. Skin moisture was measured before and after the intervention using digital skin moisture analyzer EH900U. Within-group differences were analyzed using the Wilcoxon signed-rank test, while differences among intervention groups were assessed at a significance level of 0.05. Mean skin moisture increased from 34.6±3.1% to 37.1±5.1% in the 5% group, from 34.8±4.8% to 37.9±4.9% in the 10% group, and from 37.0±5.3% to 45.6±4.3% in the 15% group. Significant improvements were observed in all groups (p=0.041, p=0.026, and p=0.0001, respectively), with a significant difference among concentrations (p=0.0017). The 15% Loranthus sp. liquid soap demonstrated the greatest improvement in skin moisture and showed potential to improve skin moisture in pregnant women with gestational diabetes mellitus. Further studies with larger sample sizes, longer follow-up periods, and an appropriate control group are needed to confirm these findings.
Potential of Stevia rebaudiana as a Safe Sweetener Alternative for Women with Gestational Diabetes Mellitus Magdalena Martha Tompunuh; Siti Choirul Dwi Astuti; Hasnawatty Surya Porouw; Rabia Zakaria; Dyah Noviawati Setya Arum; Munica Rita Hernayanti
MEDICA (International Medical Scientific Journal) Vol. 8 No. 8 (2026): MEDICA (International Medical Scientific Journal)
Publisher : Borneo Scientific Publishing

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53770/medica.v8i8.1267

Abstract

Gestational diabetes mellitus (GDM) is a common metabolic disorder during pregnancy and is associated with adverse maternal and fetal outcomes. Dietary modification, particularly reducing the intake of added sugars, is an important component of glycemic management. This study aimed to examine the effect of replacing conventional sugar with Stevia rebaudiana liquid sweetener on fasting blood glucose among pregnant women with GDM. A quasi-experimental pre–posttest control group design was conducted among 120 pregnant women with GDM at Pilolodaa Community Health Center, Gorontalo, Indonesia. Participants were allocated to an intervention group receiving 25 drops of liquid Stevia rebaudiana daily (n = 60) or a control group receiving 25 g of conventional sugar daily (n = 60) for 30 days. The assigned sweetener was used as a replacement for the sweetening component of the participants’ usual diet. Fasting blood glucose was measured in the morning after an overnight fast of at least 8 hours using a calibrated glucometer before and after the intervention. Baseline characteristics were assessed to evaluate comparability between groups. The intervention group showed a reduction in mean fasting blood glucose from 163.5 ± 19.8 mg/dL to 128.7 ± 15.6 mg/dL, whereas the control group decreased from 161.8 ± 20.1 mg/dL to 156.9 ± 18.7 mg/dL. The mean reductions were 34.8 and 4.9 mg/dL, respectively, resulting in a between-group mean difference of 29.9 mg/dL (p < 0.001). Overall, 90.0% of participants in the Stevia rebaudiana group experienced a reduction in fasting blood glucose. These findings indicate that replacing conventional sugar with liquid Stevia rebaudiana was associated with a greater reduction in fasting blood glucose over 30 days among pregnant women with GDM. However, given the quasi-experimental design and the possibility of uncontrolled confounding factors, the observed reduction should not be interpreted as definitive evidence of a specific effect of Stevia rebaudiana. Further studies with randomized designs and longer follow-up are needed to confirm these findings.
Co-Authors Ayu Nala El Muna Haerussana Dicki Bakhtiar Purkon Dyah Noviawati Setya Arum Magdalena Martha Tompunuh Munica Rita Hernayanti Nancy Oiii Rabia Zakaria Siti Choirul Dwi Astuti