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All Journal Acta Interna : The Journal of Internal Medicine PREPOTIF : Jurnal Kesehatan Masyarakat
Nugraha, Doddy Rizqi
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Health Professions Medicine & Pharmacology Public Health

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The Effect of Weight Gain on Recurrence During Hormonal Therapy in Breast Cancer with Positive Estrogen Receptor and Negative Her2 Subtype Nugraha, Doddy Rizqi; Taroeno-Hariadi, Kartika Widayati; Hardianti, Mardiah Suci
Acta Interna The Journal of Internal Medicine Vol 11, No 1 (2021): Acta Interna The Journal of Internal Medicine
Publisher : Faculty of Medicine Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/actainterna.94634

Abstract

Background. Weight gain is found in patients with positive estrogen subtype breast cancer. The effect of weight gain on breast cancer recurrence is still being debated and associated with a poor prognosis. Being overweight is associated with an increase in estrogen production by adipose tissue.Methods. A retrospective and prospective cohort study with data collection was conducted from July 2018 - June 2019 at the outpatient unit of Dr. Sardjito Hospital. We reviewed medical records of patients who came from January 2013 - July 2018.  Three categories of weight gain:  weight loss, increase 0 - 5%, and increase > 5% from baseline will be evaluated.Statistical Analysis. The relationship between weight gain and some risk factors of recurrence was analyzed with cox regression and multivariate logistic regression tests. The Kaplan Meier method is used to show lifetime data.Result. Weight gain in breast cancer patients with positive Her2-negative estrogen receptor subtypes was not associated with recurrence (p = 0.264; HR 0.637; 95% CI 0.289 - 1.405). Patients with body mass index ≥ 25 kg / m2 at diagnosis had a lower risk of relapse than patients with body mass index < 25 kg / m2 (p = 0.026; HR 0.461; 95% CI, 0.234 - 0.912).Conclusions Weight gain after diagnosis in breast cancer patients with positive estrogen receptor-negative Her2 subtypes receiving hormonal therapy is not associated with recurrence.
HUBUNGAN NEUTROPHIL LYMPHOCYTE RATIO PADA KEJADIAN FRAKTUR FRAGILITAS PASIEN GERIATRI DI RSUD WALED PERIODE AGUSTUS 2022 - JULI 2024 Lutfi, Yafi Zhafira; Dewangga, Taufan Herwindo; Nugraha, Doddy Rizqi
PREPOTIF : JURNAL KESEHATAN MASYARAKAT Vol. 9 No. 2 (2025): AGUSTUS 2025
Publisher : Universitas Pahlawan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/prepotif.v9i2.46762

Abstract

Secara global, diperkirakan 1 dari 3 wanita dan 1 dari 5 pria yang berusia di atas 50 tahun akan mengalami patah tulang akibat osteoporosis di sisa hidupnya. Menurut hasil Riset Kesehatan Dasar (RISKESDAS) 2018 Provinsi Jawa Barat, prevalensi patah tulang mencapai 7,44% pada usia 65–74 tahun, sementara untuk usia ≥75 tahun mencapai 18,94%. Hal ini dapat terjadi karena penurunan kepadatan mineral tulang pada usia lanjut. Penelitian ini bertujuan untuk mengetahui hubungan Neutrophil Lymphocyte Ratio (NLR) terhadap kejadian fraktur fragilitas pada pasien geriatri di RSUD Waled periode Agustus 2022 – Juli 2024. Penelitian ini menggunakan metode observasional analitik dengan desain cross sectional serta melibatkan 105 responden. Analisis data dilakukan dengan metode uji rank Spearman. Hasil analisis menunjukkan bahwa terdapat korelasi signifikan antara NLR dan fraktur fragilitas dengan p-value 0,001 dan kekuatan korelasi sebesar 0,329, yang berarti semakin tinggi NLR, semakin tinggi kejadian fraktur fragilitas. Hal ini menunjukkan bahwa terdapat hubungan yang signifikan dan positif antara kedua variabel tersebut. Dapat disimpulkan bahwa semakin tinggi Neutrophil Lymphocyte Ratio (NLR), semakin tinggi pula kejadian fraktur fragilitas.
Co-Authors Dewangga, Taufan Herwindo Kartika Widayati Taroeno Hariadi Lutfi, Yafi Zhafira Mardiah Suci Hardianti