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All Journal Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice) Jurnal Kesehatan Pharmaceutical Journal of Indonesia Hubungan Tingkat Pengetahuan Petugas Pengelola Obat dengan Tingkat Ketersediaan Obat Di Puskesmas Kota Malang Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice)
Hartono, Ruddy
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Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health

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Pola Penggunaan Antihipertensi pada Pasien Diabetes Mellitus Tipe 2 di Poli Penyakit Dalam RS Bhayangkara Surabaya Pramadani, Yana; Hasmono, Didik; Kasih, Elisabeth; Hartono, Ruddy
Jurnal Farmasi Sains dan Terapan Vol 5, No 2 (2018)
Publisher : Jurnal Farmasi Sains dan Terapan

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (233.028 KB) | DOI: 10.33508/jfst.v5i2.2137

Abstract

Diabetes mellitus (DM) is a metabolic disease characterized by symptoms of hyperglycemia. This disease can be caused due to abnormalities in insulin secretion, insulin action or both. Management of diabetes mellitus in general is to improve the quality of life of people with diabetes, namely to eliminate complaints of diabetes mellitus, improve quality of life, and reduce the risk of acute complications; to achieve this goal their blood pressure must be controlled using antihypertensive therapy. The purpose of this study was to examine the pattern of antihypertensive drug use related to the type, dose, and frequency of administration in reducing blood pressure in patients with type 2 diabetes mellitus in the internal medicine clinic of Bhayangkara Hospital Surabaya. The method of this study was observational because researchers did not provide treatment directly to patients. Data were collected retrospectively between August 1 and September 15, 2015. The results showed 80 patients (48%) used single therapy and 86 patients (52%) used combination therapy. The antihypertensive drug that is often used as a single therapy is valsartan (1x80 mg) given orally in 16 patients (20%) and as a combination is valsartan (1x80 mg) + amlodipine (1x10 mg).
Profil Terapi Diare Akut pada Pasien Anak Rawat Inap di Rumah Sakit Bhayangkara Surabaya Sandra, Pipit; Hasmono, Didik; Kasih, Elisabeth; Hartono, Ruddy
Jurnal Farmasi Sains dan Terapan Vol 4, No 2 (2017)
Publisher : Jurnal Farmasi Sains dan Terapan

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (302.653 KB) | DOI: 10.33508/jfst.v4i2.2184

Abstract

Acute diarrhea in children is defined as defecation more than 3 times per day, with changes in the consistency of feces into fluids with or without mucus and blood lasting either less than a week or up to 14 days, but not more than 14 days in children or infant. Treatment of acute diarrhea can shorten the duration of diarrhea and eradicate the organism which causes the disease. The purpose of this research was to analyze the profile of acute diarrhea treatment in hospitalized pediatric patients at Bhayangkara Hospital Surabaya including the type, dosage, route and the timing of administration which is related to the patient’s medical record data. This research is an observational study in the form of retrospective study in patients with acute diarrhea with a t o t a l sampling technique. The results showed the most commonly used medications for acute diarrhea in children were parenteral rehydration fluid of KDN-1 of (41 patients, 80%) with the most widely used dose (500 cc / 4 hours → 1000 cc / 24 h) IV, t h e pa t t e r n o f single antibiotic use was (43 patients, 84%), the penicillin group, ampicillin, as many as (22 patients, 44%) with the most widely used dose (4 x 250 mg) IV, the most commonly prescribed single antibiotic when discharged from the hospital was cephalosporin group, cefixime, with 17 patients (33%), with the most widely used dose (2 x 20 mg) P.O, sinbiotic with (36 patients, 70%) and the most widely used was dose (1 x 1 sachet) P.O, zinc with (49 patients, 96%) and the most widely used was dose (1 x 1 cth) P.O, vitamin A with (21 patients, 41%), and the most widely used was dose (1 x 500 IU) P.O, antidiarrhea dioctahedral smectite was (43 patients, 84%) and the most commonly used was dose (3 x 1/3 sachets) P.O.
Studi Penggunaan Antihipertensi Golongan Angiotensin Receptor Blockers Terhadap Pasien Gagal Ginjal Kronik Stadium V di Rumah Sakit Bhayangkara Surabaya Bura, Ursula Dua Klowe; Hasmono, Didik; Surdijati, Siti; Hartono, Ruddy
Jurnal Farmasi Sains dan Terapan Vol 4, No 2 (2017)
Publisher : Jurnal Farmasi Sains dan Terapan

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (341.933 KB) | DOI: 10.33508/jfst.v4i2.2185

Abstract

Chronic renal failure is functional or structural kidney damage for more than 3 (three) months with or without a decrease in the Glomerular Filtration Rate (GFR), manifested as one of the pathological abnormalities or a sign of kidney damage, including blood or urine composition abnormalities or radiology abnormalities. In addition, chronic renal failure is also defined as a condition of GFR value of less than 60 ml / minute / 1.73 m2, for more than 3 (three) months with or without kidney damage. One of the risk factor for chronic renal failure is hypertension. The purpose of antihypertensive administration is to prevent further damage to other organs, and also to reduce blood pressure in patients with chronic renal failure with a target of ≤ 140 mmHg. Angiotensin Receptor Blockers (ARB) is a first-line therapy used to reduce blood pressure so that it can delay kidney damage. The purpose of this study was to determine the pattern of antihypertensive drug use in the ARB class in patients with stage V chronic renal failure at Bhayangkara Hospital in Surabaya which was associated with clinical and laboratory data. The study was conducted observationally with a descriptive research design and retrospective data collection. The results showed that those who met the inclusion criteria were 30 patients using antihypertensive ARB therapy, where the highest number of sexes were 67% male and 33% female, the highest populations at the age of 31-70 years, the highest populations was 90% for ARB use and other antihypertensive drug and a single ARB use of 10 %, the most common combination ofantihypertensive group is ARB and Calsium Channel Blocker (CCB) 41%. The patient’s blood pressure mostly meets the target of ≤ 140 mmHg.
The Effectiveness Of Atorvastatin On Kidney Function In Outpatient Diabetic Nephrophaty Patients Hasmono, Didik; Tanasy, Marledy; Firandi, Adelia; Hartono, Ruddy; Hanum, Putri Safitri
Pharmaceutical Journal of Indonesia Vol. 9 No. 1 (2023)
Publisher : Brawijaya University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.pji.2023.009.01.1

Abstract

Introduction: Dyslipidemia can damage the kidneys through increased oxidative stress. Statins can be used as adjunctive therapy to standard treatment with ACEIs or ARBs to improve renoprotection. Objective: The study is that to analyze the effectiveness atorvastatin on changes in kidney function in patients diabetic nephropathy. Methods: It was observational study. Samples were taken prospectively from diabetic nephropathy patients receiving atorvastatin at the Interna Polyclinic of the Bhayangkara Hospital Surabaya namely November 2021 – January 2022. Patients aged 18 – 80 years received atorvastatin for ≤3 months before the study was conducted, with GFR stages 3A, 3B, and 4, with mild, moderate, and severe albuminuria degrees. Results: There are several patients which receive ARBs, namely candesartan and ketoacid which can affect the results of the analysis so that different tests are conducted in the three groups, the result shows a significant decrease in BUN values in the sample group which receives additional ketoacid therapy (p <0.05); besides, a decrease in parameters albuminuria in the group with additional 16 mg candesartan therapy which is not significant. Conclusion: The administration atorvastatin alone 20 mg or in combination with candesartan 16 mg and ketoacid on kidney function after 3 months of use can prevent the progression of diabetic nephropathy. Key words: Atorvastatin; Diabetic Nephropathy; Kidney Function
The Effectiveness Of Atorvastatin On Kidney Function In Outpatient Diabetic Nephrophaty Patients Hasmono, Didik; Tanasy, Marledy; Firandi, Adelia; Hartono, Ruddy; Hanum, Putri Safitri
Pharmaceutical Journal of Indonesia Vol. 9 No. 1 (2023)
Publisher : Brawijaya University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.pji.2023.009.01.1

Abstract

Introduction: Dyslipidemia can damage the kidneys through increased oxidative stress. Statins can be used as adjunctive therapy to standard treatment with ACEIs or ARBs to improve renoprotection. Objective: The study is that to analyze the effectiveness atorvastatin on changes in kidney function in patients diabetic nephropathy. Methods: It was observational study. Samples were taken prospectively from diabetic nephropathy patients receiving atorvastatin at the Interna Polyclinic of the Bhayangkara Hospital Surabaya namely November 2021 – January 2022. Patients aged 18 – 80 years received atorvastatin for ≤3 months before the study was conducted, with GFR stages 3A, 3B, and 4, with mild, moderate, and severe albuminuria degrees. Results: There are several patients which receive ARBs, namely candesartan and ketoacid which can affect the results of the analysis so that different tests are conducted in the three groups, the result shows a significant decrease in BUN values in the sample group which receives additional ketoacid therapy (p <0.05); besides, a decrease in parameters albuminuria in the group with additional 16 mg candesartan therapy which is not significant. Conclusion: The administration atorvastatin alone 20 mg or in combination with candesartan 16 mg and ketoacid on kidney function after 3 months of use can prevent the progression of diabetic nephropathy. Key words: Atorvastatin; Diabetic Nephropathy; Kidney Function
STUDI PENGGUNAAN DEKSAMETASON PADA PASIEN COVID-19 DERAJAT BERAT DENGAN KOMORBID DIABETES MELLITUS Hasmono, Didik; As-Shiddiq, Hasbi; Insyirah Idris, Anissah; Agriawan Sudirman; Hartono, Ruddy; Subhan, Mohammad
Jurnal Kesehatan Vol 16 No 2 (2023): : JURNAL KESEHATAN
Publisher : Universitas Islam Negeri Alauddin Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24252/kesehatan.v16i2.28712

Abstract

Administration of Dexamethasone in patients with diabetes needs attention because corticosteroids can increase blood glucose concentrations. Therefore, this study aims to determine the effectiveness of using Dexamethasone in patients with severe COVID-19 and how to regulate blood glucose in patients with severe COVID-19 in patients with comorbid Diabetes Mellitus. Inclusion criteria for severe COVID-19 patients with comorbid Diabetes Mellitus who use Dexamethasone and therapy groups and receive insulin therapy with or without OAD in inpatient installations. The sample data obtained from the patient's medical records were 27 patients who met the inclusion and exclusion criteria consisting of 70% male and 30% female. Dexamethasone dose of 1 x 6 mg iv mostly uses combination therapy A, the duration of administration is 8 days, and has an average length of stay of 13 days. The shortest average length of hospitalization was 12 days for patients receiving dexamethasone with therapy C for 10 days, while therapy B for 5 days had an average hospitalization of 14 days. Administration of Dexamethasone dose of 1 x 6 mg iv is effective in severe COVID-19 patients with comorbid Diabetes Mellitus based on the length of hospitalization, respectively 13 days, 14 days, and 12 days with an improvement in the clinical condition of oxygen saturation by 91%, 100%, 100%; RT-PCR/Rapid Ag became negative 74%, 100%, 100%; improvement of chest x-ray results, namely 83%, 33%, 100%. The effect of glucocorticoid dexamethasone in comorbid Diabetes Mellitus patients is regulated by administering long-acting insulin, rapid-acting insulin, and oral anti-diabetic.
Pola Penggunaan Antihipertensi pada Pasien Diabetes Mellitus Tipe 2 di Poli Penyakit Dalam RS Bhayangkara Surabaya Pramadani, Yana; Hasmono, Didik; Kasih, Elisabeth; Hartono, Ruddy
Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice) Vol. 5 No. 2 (2018)
Publisher : Faculty of Pharmacy, Widya Mandala Surabaya Catholic University, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33508/jfst.v5i2.2137

Abstract

Diabetes mellitus (DM) is a metabolic disease characterized by symptoms of hyperglycemia. This disease can be caused due to abnormalities in insulin secretion, insulin action or both. Management of diabetes mellitus in general is to improve the quality of life of people with diabetes, namely to eliminate complaints of diabetes mellitus, improve quality of life, and reduce the risk of acute complications; to achieve this goal their blood pressure must be controlled using antihypertensive therapy. The purpose of this study was to examine the pattern of antihypertensive drug use related to the type, dose, and frequency of administration in reducing blood pressure in patients with type 2 diabetes mellitus in the internal medicine clinic of Bhayangkara Hospital Surabaya. The method of this study was observational because researchers did not provide treatment directly to patients. Data were collected retrospectively between August 1 and September 15, 2015. The results showed 80 patients (48%) used single therapy and 86 patients (52%) used combination therapy. The antihypertensive drug that is often used as a single therapy is valsartan (1x80 mg) given orally in 16 patients (20%) and as a combination is valsartan (1x80 mg) + amlodipine (1x10 mg).
Profil Terapi Diare Akut pada Pasien Anak Rawat Inap di Rumah Sakit Bhayangkara Surabaya Sandra, Pipit; Hasmono, Didik; Kasih, Elisabeth; Hartono, Ruddy
Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice) Vol. 4 No. 2 (2017)
Publisher : Faculty of Pharmacy, Widya Mandala Surabaya Catholic University, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33508/jfst.v4i2.2184

Abstract

Acute diarrhea in children is defined as defecation more than 3 times per day, with changes in the consistency of feces into fluids with or without mucus and blood lasting either less than a week or up to 14 days, but not more than 14 days in children or infant. Treatment of acute diarrhea can shorten the duration of diarrhea and eradicate the organism which causes the disease. The purpose of this research was to analyze the profile of acute diarrhea treatment in hospitalized pediatric patients at Bhayangkara Hospital Surabaya including the type, dosage, route and the timing of administration which is related to the patient’s medical record data. This research is an observational study in the form of retrospective study in patients with acute diarrhea with a t o t a l sampling technique. The results showed the most commonly used medications for acute diarrhea in children were parenteral rehydration fluid of KDN-1 of (41 patients, 80%) with the most widely used dose (500 cc / 4 hours → 1000 cc / 24 h) IV, t h e pa t t e r n o f single antibiotic use was (43 patients, 84%), the penicillin group, ampicillin, as many as (22 patients, 44%) with the most widely used dose (4 x 250 mg) IV, the most commonly prescribed single antibiotic when discharged from the hospital was cephalosporin group, cefixime, with 17 patients (33%), with the most widely used dose (2 x 20 mg) P.O, sinbiotic with (36 patients, 70%) and the most widely used was dose (1 x 1 sachet) P.O, zinc with (49 patients, 96%) and the most widely used was dose (1 x 1 cth) P.O, vitamin A with (21 patients, 41%), and the most widely used was dose (1 x 500 IU) P.O, antidiarrhea dioctahedral smectite was (43 patients, 84%) and the most commonly used was dose (3 x 1/3 sachets) P.O.
Studi Penggunaan Antihipertensi Golongan Angiotensin Receptor Blockers Terhadap Pasien Gagal Ginjal Kronik Stadium V di Rumah Sakit Bhayangkara Surabaya Bura, Ursula Dua Klowe; Hasmono, Didik; Surdijati, Siti; Hartono, Ruddy
Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice) Vol. 4 No. 2 (2017)
Publisher : Faculty of Pharmacy, Widya Mandala Surabaya Catholic University, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33508/jfst.v4i2.2185

Abstract

Chronic renal failure is functional or structural kidney damage for more than 3 (three) months with or without a decrease in the Glomerular Filtration Rate (GFR), manifested as one of the pathological abnormalities or a sign of kidney damage, including blood or urine composition abnormalities or radiology abnormalities. In addition, chronic renal failure is also defined as a condition of GFR value of less than 60 ml / minute / 1.73 m2, for more than 3 (three) months with or without kidney damage. One of the risk factor for chronic renal failure is hypertension. The purpose of antihypertensive administration is to prevent further damage to other organs, and also to reduce blood pressure in patients with chronic renal failure with a target of ≤ 140 mmHg. Angiotensin Receptor Blockers (ARB) is a first-line therapy used to reduce blood pressure so that it can delay kidney damage. The purpose of this study was to determine the pattern of antihypertensive drug use in the ARB class in patients with stage V chronic renal failure at Bhayangkara Hospital in Surabaya which was associated with clinical and laboratory data. The study was conducted observationally with a descriptive research design and retrospective data collection. The results showed that those who met the inclusion criteria were 30 patients using antihypertensive ARB therapy, where the highest number of sexes were 67% male and 33% female, the highest populations at the age of 31-70 years, the highest populations was 90% for ARB use and other antihypertensive drug and a single ARB use of 10 %, the most common combination ofantihypertensive group is ARB and Calsium Channel Blocker (CCB) 41%. The patient’s blood pressure mostly meets the target of ≤ 140 mmHg.
Co-Authors Agriawan Sudirman Bura, Ursula Dua Klowe Didik Hasmono Elisabeth Kasih Hanum, Putri Safitri Hasbi As-Shiddiq Heni Pujiastuti Insyirah Idris, Anissah Mohammad Subhan Pramadani, Yana RR. Ella Evrita Hestiandari Sandra, Pipit Siti Surdijati, Siti Tanasy, Marledy