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All Journal Pharmademica: Jurnal Kefarmasian dan Gizi
Mukhlis Sanuddin
Prodi Farmasi, Fakultas Farmasi, Sekolah Tinggi Ilmu Kesehatan Harapan Ibu Jambi
Chemistry Public Health

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Uji Sitotoksik Ekstrak Etanol Daun Medang Gatal (Schima wallichii (DC.) Korth.) Menggunakan Metode MTT Assay terhadap Sel Kanker Payudara MCF-7 Indri Meirista; Mukhlis Sanuddin; Dhea Adriyani
PHARMADEMICA : Jurnal Kefarmasian dan Gizi Vol 6 No 1 (2026): April - September
Publisher : LPPM-KI - POLTEKKES PIM (Formerly AKAFARMA-AKFAR PIM

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.54445/pharmademica.v6i1.148

Abstract

Breast cancer is one of the leading causes of death among women worldwide. The search for anticancer agents from natural products continues to develop due to their lower side effects compared to conventional chemotherapy. This study aimed to evaluate the cytotoxic activity of the ethanol extract of Schima wallichii DC. Korth (Medang gatal) leaves against MCF-7 breast cancer cells in vitro using the MTT assay method. The simplicia was prepared from fresh leaves that were dried, powdered, and extracted by maceration using 96% ethanol, yielding 23.9%. LC-MS analysis identified bioactive compounds such as kaempferol, tangeretin, naringenin, carnosic acid, and kaempferol-3-O-rhamnoside, which are known to possess anticancer potential. The cytotoxic assay was performed at concentrations of 1000, 500, 250, 125, and 62.5 µg/mL. The results showed a significant decrease in cell viability with increasing extract concentration. Linear regression analysis revealed an IC₅₀ value of 403 µg/mL, categorized as moderate toxicity based on the National Cancer Institute (NCI) criteria. These findings indicate that the ethanol extract of Medang gatal leaves has potential as a natural source for anticancer drug development, although further studies are required to isolate the active compounds and evaluate in vivo effects.
Co-Authors Dhea Adriyani Indri Meirista