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All Journal Biomedika
Andhita Apriliana
Universitas Lambung Mangkurat, Banjarmasin
Biochemistry, Genetics & Molecular Biology Medicine & Pharmacology

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RISK FACTORS OF QTC INTERVAL PROLONGATION IN HEMODIALYSIS PATIENTS Hendra Wana Nur'amin; Djallalludin; Andhita Apriliana; Farhanaqilah Mazaya; Hijratun Nisa
Biomedika Vol 18, No 2 (2026): Biomedika August 2026
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/biomedika.v18i2.16821

Abstract

QTc interval prolongation is an important risk factor for fatal arrhythmias and sudden cardiac death. Identifying factors associated with QTc prolongation may help prevent cardiovascular complications. This study aimed to analyze clinical factors associated with the risk of QTc prolongation in hemodialysis patients. This study was conducted with a cross-sectional approach. Bivariate logistic regression analysis was performed to analyze the association of sex, age, body mass index (BMI), and comorbidities (diabetes mellitus, hypertension, heart failure, pneumonia, anemia, and hyperkalemia) with QTc prolongation. 189 subjects were enrolled and divided into two groups based on QTc duration ≥500 ms ( n =41) and <500 ms ( n =148). Of all variables, gender showed a significant association with QTc prolongation (p=0.02; prevalence odds ratio (POR)=2.40; 95% CI: 1.15-4.99), with women having a higher risk of QTc interval ≥500 ms than men. Risk factors such as age >60 years, BMI, diabetes mellitus, hypertension, heart failure, pneumonia, anemia, and hyperkalemia did not show a significant association (p>0.05). These findings support the need for routine ECG monitoring, especially in female patients, to prevent arrhythmias and cardiovascular mortality.
Co-Authors Djallalludin Farhanaqilah Mazaya Hendra Wana Nur'amin Hijratun Nisa