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All Journal JC-T (Journal Cis-Trans) : Jurnal Kimia dan Terapannya
Ana Nurjanah
Program Studi D-III Farmasi Akademi Farmasi Putra Indonesia Malang
Biochemistry, Genetics & Molecular Biology

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Inhibisi Xantin Oksidase oleh Ekstrak Daun Salam (Syzygium Polyanthum) Nur Candra Eka Setiawan; Ana Nurjanah
JC-T (Journal Cis-Trans) : Jurnal Kimia dan Terapannya Vol. 2 No. 1 (2018)
Publisher : Universitas Negeri Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.17977/um026v2i12018p025

Abstract

Xhantine oxidase is an enzyme that plays a role in the formation of uric acid. Xanthine oxidase catalyzeshypoxanthine into xantin and then becomes uric acid. Bay leaf plants can lower blood uric acid levelbecause it contains secondary metabolites such as flavonoid, tannin, and essential oil. This reseachaimed are to find out xhantine oxidase inhibition by bay leaf extract. This reseach use experimentalresearch method which done in pharmacognosi of pharmacy of Putra Indonesia Malang. The reseachinclude extraction, isolation of xanthine oxidase enzyme, enzyme activity test and enzyme inhibition test.Testing of enzyme activity of xanthine oxidase inhibition using spectrophotometric at λ290 nm. Theresult showes that in variant concentrations of 5 ppm, 10 ppm, 20 ppm, 50 ppm dan 100 ppm wereproduced inhibitions is %, 0%, 100%, 100%, 0%. Allopurinol is used as a positive control with the sameconcentration, the % inhibition is 100%, 0%, 0%, 0%, dan 100%. Based on the result, the bay leafextract with a concentration of 5 ppm has 100% inhibition equivalent to allopurinol 5 ppm.Concentration 100 ppm of bay leaf extract not show inhibitory activity.
Co-Authors Nur Candra Eka Setiawan