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All Journal JC-T (Journal Cis-Trans) : Jurnal Kimia dan Terapannya
Maskur Maskur
PTRR-BATAN Kawasan PUSPIPTEK Serpong, Indonesia
Biochemistry, Genetics & Molecular Biology

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Validasi Pembuatan Senyawa Bertanda 131I-MIBG di PTRR Batan Untuk Diagnosis dan Terapi Neuroblastoma Yono Sugiharto; Maskur Maskur; Chairuman Chairuman
JC-T (Journal Cis-Trans) : Jurnal Kimia dan Terapannya Vol. 4 No. 1 (2020)
Publisher : Universitas Negeri Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.17977/um0260v4i12020p001

Abstract

Neuroblastoma is a type of neuroendocrine cancer that is very dangerous, but can be cured if earlydetected and appropriate therapy. Center for Radioisotope and Radiopharmaceutical Technology BATANSerpong has been succeeded in making labelled compounds131I-MIBG for early detection of neuroblastomacancer. Iodine-131 (I-131)-MIBG was prepared by reacting 127I-MIBG sulfate and Na131I using CuSO4catalyst and reducing agent as sodium bisulphite, pH = 3-4 with CH3COOH.The solution was refluxed at atemperature of 1600C so that the resulting of 131I-MIBG labelled compound.The radiochemical purity of theproduct was tested by chromatographic, using whatman paper number 1 asstationary phase and the mobilephase containing of n.butanol liquid mixture: acetic acid: water (5: 2: 1), and radionuclide purity test usinggamma spectrometer. Radiochemical and radionuclide purity131I-MIBG (diagnosis) was carried outof99.72% ± 0.32 and 99.99% ± 0.00 respectively. The labelled compound 131I-MIBG (therapy) withradioactivity dose of 25 mCi / vial was obtained of radiochemical purity = 98.33% ± 0.53 and radionuclidepurity = 99.99% ± 0.00, whereas radiochemical purity and radionuclide purity of131I-MIBG (therapy) withradioactivity dose of 50 mCi / vial was obtained 98.83% ± 0.32 and 99.99% ± 0.00 respectively.
Co-Authors Chairuman Chairuman Yono Sugiharto