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All Journal JC-T (Journal Cis-Trans) : Jurnal Kimia dan Terapannya
Rana Raad Zanzal
University of Samarra
Biochemistry, Genetics & Molecular Biology

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Biochemical Alterations in Kidney and Liver Function in Individuals with Severe Pre-eclampsia Nuha Ali Hadi Ali_Samarrai; Maytham Mohammad Bakr; Rana Raad Zanzal
JC-T (Journal Cis-Trans) : Jurnal Kimia dan Terapannya Vol. 10 No. 1 (2026)
Publisher : Universitas Negeri Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.17977/um0260v10i12026p008

Abstract

Preeclampsia (PE) is a multisystem disorder that complicates 2 to 8 % of pregnancies worldwide and is a major cause of maternal and fetal morbidity and mortality. Objective: To evaluate biochemical biomarkers of kidney and liver function and inflammatory biomarkers (TNF-α and IL-6) in women with severe pre-eclampsia and compare them with healthy pregnant controls. Methods: The present cross-sectional study was performed on 70 pregnant women with preeclampsia and 30 healthy pregnant controls with gestational ages >20 weeks. Serum levels of TNF-α, IL-6 and Cystine C were estimated by Elisa-based assays and liver and kidney function Biochemical tests were performed using spectrophotometer according to the manufacturer’s instructions. Results: Significant difference was observed in blood urea nitrogen and serum creatinine in severe pre-eclampsia as compared with healthy controls (P < 0.001). Liver function tests and bilirubin was also significantly higher in severe preeclampsia (P < 0.001). In preeclamptic group, the levels of TNF- α and IL-6 were significantly increased. Conclusion: Severe preeclampsia was associated with significant changes in kidney and liver biochemical parameters and increased inflammatory biomarkers.
Co-Authors Maytham Mohammad Bakr Nuha Ali Hadi Ali_Samarrai