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All Journal JC-T (Journal Cis-Trans) : Jurnal Kimia dan Terapannya
Silvi Anjarsari
STIKes Karya Putra Bangsa
Biochemistry, Genetics & Molecular Biology

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Evaluation of the Analgesic Efficacy of Ethanolic Extract of Majapahit (Crescentia cujete L.) Leaves in Male Swiss Webster Mice Using the Hot Plate Method Rahma Diyan Martha; Choirul Huda; Silvi Anjarsari; Danar Danar
JC-T (Journal Cis-Trans) : Jurnal Kimia dan Terapannya Article in Press
Publisher : Universitas Negeri Malang

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Abstract

Majapahit (Crescentia cujete L.) leaves contain secondary metabolites, particularly flavonoids, which exert analgesic effects by inhibiting cyclooxygenase activity, thereby reducing prostaglandin biosynthesis from arachidonic acid and alleviating pain. This study evaluated the analgesic efficacy of an ethanolic extract of Majapahit leaves in male Swiss Webster mice using the hot plate method. Pain responses were recorded at 0, 30, 60, 90, and 120 min post-administration. The results demonstrated that the optimal analgesic effect was achieved at a dose of 375 mg/kg body weight (BW), yielding an efficacy level of 82.80%, which was comparable to the positive control group treated with mefenamic acid. Statistical analysis performed using SPSS via one-way ANOVA followed by Tukey's HSD post-hoc test revealed no significant difference between the 375 mg/kg BW dose group and the positive control group (p > 0.05). These findings indicate that the 375 mg/kg BW dose has potential as an effective analgesic dose and may provide a basis for further investigation into its development and application as a potential analgesic agent.
Co-Authors Choirul Huda Danar Danar