Abstract. Academic stress is a psychological condition commonly experienced by students, particularly final-year students who are completing their undergraduate thesis, and it may affect physiological regulation, including sleep patterns, thereby reducing sleep quality. Poor sleep quality has negative effects on cognitive function, mental health, and academic performance. This study aimed to describe academic stress and sleep quality and to analyze the effect of academic stress on sleep quality among students of the Faculty of Medicine, Universitas Islam Bandung (UNISBA), who were working on their thesis during the 2024/2025 academic year. This study employed an analytic observational design with a cross-sectional approach. A total of 133 students were selected using purposive sampling based on inclusion and exclusion criteria. Academic stress was measured using the Perception of Academic Stress (PAS) questionnaire, while sleep quality was assessed using the Pittsburgh Sleep Quality Index (PSQI). Data were analyzed using the Chi-square test and simple linear regression. The results showed that 64% of respondents had poor sleep quality and 74% had low levels of academic stress. There was a significant association between academic stress and sleep quality (p < 0.001). Regression analysis demonstrated that academic stress had a negative effect on sleep quality, indicating that higher levels of academic stress were associated with poorer sleep quality. These findings indicate that academic stress is an important factor influencing sleep quality among students who are completing their thesis; therefore, academic support and stress management interventions are needed to improve student well-being. Abstrak. Stres akademik merupakan kondisi psikologis yang umum dialami mahasiswa, terutama mahasiswa tingkat akhir yang sedang menyusun skripsi, dan dapat memengaruhi regulasi fisiologis tubuh termasuk pola tidur sehingga menurunkan kualitas tidur. Kualitas tidur yang buruk berdampak pada fungsi kognitif, kesehatan mental, dan performa akademik. Penelitian ini bertujuan untuk mengetahui gambaran stres akademik dan kualitas tidur serta menganalisis pengaruh stres akademik terhadap kualitas tidur pada mahasiswa Fakultas Kedokteran Universitas Islam Bandung (UNISBA) yang sedang mengerjakan skripsi tahun akademik 2024/2025. Penelitian ini menggunakan desain observasional analitik dengan pendekatan potong lintang. Subjek penelitian berjumlah 133 mahasiswa yang dipilih menggunakan teknik purposive sampling sesuai kriteria inklusi dan eksklusi. Stres akademik diukur menggunakan kuesioner Perception of Academic Stress (PAS) dan kualitas tidur diukur menggunakan Pittsburgh Sleep Quality Index (PSQI). Analisis data dilakukan menggunakan uji Chi-Square dan regresi linier sederhana. Hasil penelitian menunjukkan bahwa 64% responden memiliki kualitas tidur buruk dan 74% memiliki tingkat stres akademik rendah. Terdapat hubungan yang bermakna antara stres akademik dan kualitas tidur (p < 0,001). Hasil analisis regresi menunjukkan bahwa stres akademik berpengaruh terhadap kualitas tidur dengan arah hubungan negatif. Disimpulkan bahwa stres akademik merupakan faktor penting yang memengaruhi kualitas tidur mahasiswa yang sedang menyusun skripsi, sehingga diperlukan dukungan akademik dan intervensi manajemen stres untuk meningkatkan kesejahteraan mahasiswa.