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All Journal Journal Pharmasci (Journal of Pharmacy and Science)
Wiranti Sri Rahayu
Muhammadiyah University Purwokerto
Biochemistry, Genetics & Molecular Biology Chemistry Health Professions Immunology & microbiology Medicine & Pharmacology

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Hydroxyapatite From Kepah Shells (Polymesoda erosa) and Its In Vitro Sunscreen Activity: Hidroksiapatit Dari Cangkang Kerang Kepah (Polymesoda erosa) dan Aktivitas Tabir Surya Secara In Vitro Pri Iswati Utami; Wiranti Sri Rahayu; Karina Festia Ramadani; Astrit Mayang Sari
Journal Pharmasci (Journal of Pharmacy and Science) Vol. 10 No. 1 (2025): Journal Pharmasci (Journal of Pharmacy and Science)
Publisher : Akademi Farmasi Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53342/pharmasci.v10i1.485

Abstract

Sunscreen innovation from natural ingredients is needed, because there are many advantages obtained from the use of these natural ingredients, such as the absence of side effects, and easy to obtain. Kepah shells (Polymesoda erosa) are found in Cilacap, Central Java. Kepah shells containing calcium carbonate can be used in the manufacture of hydroxyapatite (HAP). Hydroxyapatite can be used as a sunscreen agent that can effectively absorb the ultraviolet light. Hydroxyapatite was isolated from kepah shells (Polymesoda erosa). The analysis of HAP is done using Fourier Trasform Infra Red (FTIR) spectroscopy to find out functional groups. The sun protection factor (SPF) value of HAP was determined using the spectrophotometric UV-Vis method. FTIR spectra of HAP showed the presence of a hydroxyl group at 3039-3749 cm-1, a phosphate group at 520-621 cm-1 and a carbonate group at 1489-2156 cm-1. HAP from kepah shells has sunscreen potential with minimal protection at a concentration of 200 ppm; and ultra protection at a concentration of 1000 ppm. The average SPF result of HAP 1000 ppm clam shells is 19.23 (ultra protection) and at a concentration of 200 ppm is 0.59 (minimum protection). HAP from kepah shells has the potential to be developed as a sunscreen ingredient. The development of sun protection products still requires further research.
Authentication of Turmeric Powder from Sudan I, QuinolineYellow and Methanyl Yellow by FTIR Method Combined With Chemometric: Autentikasi Serbuk Kunyit dari Sudan I, Kuning Quinoline dan Kuning Metanil dengan Metode FTIR yang Dikombinasi Dengan Kemometrik Wiranti Sri Rahayu; Herliningsih; Asmiyenti Djaliasrin Djalil
Journal Pharmasci (Journal of Pharmacy and Science) Vol. 10 No. 1 (2025): Journal Pharmasci (Journal of Pharmacy and Science)
Publisher : Akademi Farmasi Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53342/pharmasci.v10i1.486

Abstract

Turmeric is an essential commodity widely used in the food, drug, and cosmetic industries. The high demand for turmeric leads to many possibilities of adulterating turmeric powder with synthetic dyes. This study aims to develop an ATR-FTIR analysis method combined with chemometrics to authenticate turmeric powder adulterated with synthetic dyes such as sudan I, quinoline yellow, and methanyl yellow. Turmeric powder is placed above the diamond crystal in ATR. Spectrum scanning is performed at wavenumbers 4000-400 cm-1. The spectrum obtained is then analyzed by chemometrics, namely Principal Component Analysis (PCA) and Partial Least Square (PLS). PCA score plot shows turmeric powder can be distinguished from 3 synthetic colors: sudan 1, quinoline yellow and methanyl yellow.  The results of analysis with PLS provide good calibration with an R2 value of 0.863-0.934 and RMSE value of 6.149-13.791 at wavenumbers 1581.63-871.82 cm-1. The combination of FTIR with chemometrics can be used to authenticate turmeric powder from adulterants in the form of sudan I, quinoline yellow, and methanyl yellow
Co-Authors Asmiyenti Djaliasrin Djalil Astrit Mayang Sari Herliningsih, Herliningsih Karina Festia Ramadani Pri Iswati Utami