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All Journal Indonesian Journal of Cosmetics
Angga Saputra Yasir
Rekayasa Kosmetik
Agriculture, Biological Sciences & Forestry Chemistry Economics, Econometrics & Finance Industrial & Manufacturing Engineering Medicine & Pharmacology

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STABILITY AND IRRITATION TESTING USING THE PATCH TEST METHOD OF A COMBINATION GEL FORMULATION CONTAINING ALOE VERA AND BASIL LEAF EXTRACTS Angga Saputra Yasir; Suryaneta Suryaneta; Kiki Yuli Handayani; Bagus Satria
Indonesian Journal of Cosmetics Vol. 1 No. 1 (2023)
Publisher : Institut Teknologi Sumatera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35472/ijcos.v1i1.1638

Abstract

Aloe vera and basil leaves have been recognized for their anti-inflammatory and antibacterial properties. Combining these extracts into a gel formulation offers convenience in application. However, research concerning potential irritations associated with its use remains limited. This study aims to assess irritation in humans resulting from the application of a gel formulation containing basil and aloe vera extracts using patch testing. The gel formulation is prepared with a 2% concentration of the extracts, with a 1:1 ratio of basil to aloe vera extracts. Optimization is achieved by varying carbopol concentrations and the final pH of the gel formulation. The parameters used for determining the optimal formula include organoleptic characteristics, viscosity, spreadability, adhesiveness, and pH of the formulation. The optimal formula is subsequently subjected to stability testing over four weeks and irritation testing using patch methods. A total of 25 volunteers are involved in the irritation testing. Observations are made up to 72 hours after the removal of the formulation to ensure the absence of delayed irritation effects. Aloe vera and basil extractions using ethanol as a solvent yield sequential yields of 1.7% and 3%, respectively. Quality evaluation for Formulations I (FI), II (FII), and III (FIII) includes spreadability, adhesiveness, and viscosity, as follows: (4.1 cm; 5.4 seconds; 5504 mPa.s); (6.5 cm; 4.1 seconds; 3480 mPa.s); and (5.2 cm; 4.2 seconds; 6340 mPa.s), respectively. FII is selected as the optimal formula because it exhibits wider spreadability and lower viscosity compared to FI and FIII (P <0.05). Stability testing for FII shows that the formula remains stable during storage for all quality testing parameters (P > 0.05). The Primary Irritation Index (PII) for FII has a value of 0.0216, indicating that it does not cause irritation during patch testing.
Optimization of Formula and In Vitro Activity Testing of O/W Lotion Cosmetic Formulations Containing Ethanol Extract of Cat's Whiskers Leaves (Orthosiphon aristatus) as Sunscreen Angga Saputra Yasir; Suryaneta Suryaneta; Tikarahayu Putri; Iwan Saputra; Kiki Handayani; Annisaa Zulaicha; Indah Puspita Sari; Veni Nurhayati; Aida Sholeha
Indonesian Journal of Cosmetics Vol. 2 No. 1 (2024): Indonesian Journal of Cosmetics
Publisher : Institut Teknologi Sumatera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35472/ijcos.v2i1.1809

Abstract

Exposure to ultraviolet (UV) radiation from sunlight can induce erythema, sunburn, and skin sensitivity, culminating in dermal damage. The application of sunscreen mitigates potential skin harm resulting from solar radiation. This investigation aims to ascertain the optimal formulation for lotion preparations incorporating Orthosiphon aristatus leaf extract and evaluate the sunscreen efficacy of said formulations through in vitro testing. Extraction procedures involved ethanol maceration, followed by phytochemical characterization of the resultant extract. Formulation of the extract into oil-in-water (O/W) lotion preparations was executed, with optimization conducted utilizing the Simplex Lattice Design (SLD) method, incorporating varied concentrations of stearic acid, cetyl alcohol, and olive oil to assess their impact on lotion viscosity, spreadability, and adhesion. Subsequent evaluation encompassed in vitro assessment of sunscreen activity for both the lotion and extract. Findings revealed the presence of flavonoids, saponins, and tannins in the extract. Optimal lotion formulation, determined via the SLD method, yielded concentrations of 2.00, 4.22, and 8.78 for stearic acid, cetyl alcohol, and olive oil, respectively. Formulation optimization was guided by minimizing viscosity while maximizing spreadability and adhesion. Confirmation studies underscored the predictive capacity of the SLD method in determining viscosity, spreadability, and adhesion of the cat's whiskers leaf extract lotion. SPF values for the extract and lotion were recorded as 33.63 ± 0.963 and 2.54 ± 0.001, respectively, at a concentration of 30,000 ppm.
Co-Authors Aida Sholeha Annisaa Zulaicha Indah Puspita Sari Kiki Handayani Kiki Yuli Handayani Saputra, Iwan Suryaneta Tikarahayu Putri Veni Nurhayati