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All Journal Medali Jurnal : Media Dental Intelektual ODONTO Dental Journal Odonto dental journal
Rina Kartika Sari
Sultan Agung Islamic University
Dentistry Health Professions Medicine & Pharmacology Public Health

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Effectiveness of Licorice Extract (Glycyrrhiza glabra L.) on Traumatic Ulcer with Parameter Study: Macrophage, Neutrophil, and Lymphocyte Liftia Layyinatus Syifa; Rina Kartika Sari; Dea Maynur Shalima Ismail; Rizqila Diva Pradisha
Odonto : Dental Journal Vol. 13 No. 1 (2026): April 2026
Publisher : Faculty of Dentistry, Universitas Islam Sultan Agung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30659/odj.13.1.17-25

Abstract

Background: Traumatic oral ulcers are common lesions characterized by epithelial loss, pain, and erythematous halos. Healing occurs through four stages: haemostasis, inflammation, proliferation, and remodelling. Licorice root (Glycyrrhiza glabra L.) is known for its anti-inflammatory and immunomodulatory properties. This study aimed to evaluate the effectiveness of licorice extract at various concentrations on macrophage, neutrophil, and lymphocyte cell counts during traumatic ulcer healing.Methods: A post-test only group design was used with five groups: three treatment groups receiving 5%, 10%, and 15% licorice extract, and two control groups (positive: Aloclair; negative: aquadest), each with six mice. Ulcers were induced using a heated burnisher on the labial mucosa. Treatments were applied twice daily using a nano mouth spray. After euthanasia, labial tissues were fixed, processed, and stained with Hematoxylin-Eosin for histological examination under 400× magnification.Result: Phytochemical analysis revealed high flavonoid (44.669) and saponin (38.802) contents in licorice extract. Statistical tests showed significant differences (p < 0.05) in macrophage, neutrophil, and lymphocyte counts among groups. The 10% extract group showed the highest immune cell response, suggesting optimal anti-inflammatory and immunomodulatory effects at this concentration.Conclusion: Licorice extract effectively promotes the healing of traumatic oral ulcers. Among tested concentrations, the 10% extract provided the best therapeutic effect, accelerating healing and regulating inflammatory cell activity more effectively than other doses or controls.
Effectiveness of Licorice Extract (Glycyrrhiza glabra L.) on Traumatic Ulcer with Parameter Study: Macrophage, Neutrophil, and Lymphocyte Liftia Layyinatus Syifa; Rina Kartika Sari; Dea Maynur Shalima Ismail; Rizqila Diva Pradisha
Odonto : Dental Journal Vol. 13 No. 1 (2026): April 2026
Publisher : Faculty of Dentistry, Universitas Islam Sultan Agung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30659/odj.13.1.17-25

Abstract

Background: Traumatic oral ulcers are common lesions characterized by epithelial loss, pain, and erythematous halos. Healing occurs through four stages: haemostasis, inflammation, proliferation, and remodelling. Licorice root (Glycyrrhiza glabra L.) is known for its anti-inflammatory and immunomodulatory properties. This study aimed to evaluate the effectiveness of licorice extract at various concentrations on macrophage, neutrophil, and lymphocyte cell counts during traumatic ulcer healing.Methods: A post-test only group design was used with five groups: three treatment groups receiving 5%, 10%, and 15% licorice extract, and two control groups (positive: Aloclair; negative: aquadest), each with six mice. Ulcers were induced using a heated burnisher on the labial mucosa. Treatments were applied twice daily using a nano mouth spray. After euthanasia, labial tissues were fixed, processed, and stained with Hematoxylin-Eosin for histological examination under 400× magnification.Result: Phytochemical analysis revealed high flavonoid (44.669) and saponin (38.802) contents in licorice extract. Statistical tests showed significant differences (p < 0.05) in macrophage, neutrophil, and lymphocyte counts among groups. The 10% extract group showed the highest immune cell response, suggesting optimal anti-inflammatory and immunomodulatory effects at this concentration.Conclusion: Licorice extract effectively promotes the healing of traumatic oral ulcers. Among tested concentrations, the 10% extract provided the best therapeutic effect, accelerating healing and regulating inflammatory cell activity more effectively than other doses or controls.
PROBIOTICS VS. BACTERIA: HOW LACTOBACILLUS CASEI BATTLES STREPTOCOCCUS MUTANS BIOFILM (IN VITRO) Rahmawati Sri Praptiningsih; Rina Kartika Sari; Renanda Rifki Ikhsandarujati; Rama Putranto
Media Dental Intelektual Vol. 7 No. 1 (2025): Media Dental Intelektual February 2025
Publisher : Faculty of Dentistry, Universitas Islam Sultan Agung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30659/medali.7.1.12-21

Abstract

Background:Caries formation is influenced by several factors such as teeth, microorganisms, biofilm, and also time. The initial bacteria that play an important role in biofilm formation is Streptococcus mutans. Probiotics made from these bacteria are considered capable of overcoming dental and oral health problems because they are able to suppress the biofilm which will coat and protect the mucosa from invasion by cariogenic bacteria such as caries.Purpose:To determine the effect of the probioticLactobacillus casei in reducing Streptococcus mutans biofilm growth (in vitro).Method:The research design carried out was experimental research with a post test only control group design. The research samples were divided into 3 groups, namely the chlorhexidine, distilled water and probiotic groups. Biofilm thickness testing was carried out by OD (Optical density) using an ELISA-reader. Parametric statistical test analysis using the Kruskal Wallis Test.Results:The results of the Kruskal Wallis statistical test showed P= 0.000 there is a significant difference in the 3 Streptococcus mutans thickness test groups.Conclusion:The probioticLactobacillus casei has the effect of reducing the thickness of the Streptococcus mutans biofilm
Co-Authors Dea Maynur Shalima Ismail Liftia Layyinatus Syifa Rahmawati Sri Praptiningsih Rama Putranto Renanda Rifki Ikhsandarujati Rizqila Diva Pradisha