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All Journal Medali Jurnal : Media Dental Intelektual
Rahmawati Sri Praptiningsih
Sultan Agung Islamic University
Dentistry Health Professions Public Health

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PROBIOTICS VS. BACTERIA: HOW LACTOBACILLUS CASEI BATTLES STREPTOCOCCUS MUTANS BIOFILM (IN VITRO) Rahmawati Sri Praptiningsih; Rina Kartika Sari; Renanda Rifki Ikhsandarujati; Rama Putranto
Media Dental Intelektual Vol. 7 No. 1 (2025): Media Dental Intelektual February 2025
Publisher : Faculty of Dentistry, Universitas Islam Sultan Agung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30659/medali.7.1.12-21

Abstract

Background:Caries formation is influenced by several factors such as teeth, microorganisms, biofilm, and also time. The initial bacteria that play an important role in biofilm formation is Streptococcus mutans. Probiotics made from these bacteria are considered capable of overcoming dental and oral health problems because they are able to suppress the biofilm which will coat and protect the mucosa from invasion by cariogenic bacteria such as caries.Purpose:To determine the effect of the probioticLactobacillus casei in reducing Streptococcus mutans biofilm growth (in vitro).Method:The research design carried out was experimental research with a post test only control group design. The research samples were divided into 3 groups, namely the chlorhexidine, distilled water and probiotic groups. Biofilm thickness testing was carried out by OD (Optical density) using an ELISA-reader. Parametric statistical test analysis using the Kruskal Wallis Test.Results:The results of the Kruskal Wallis statistical test showed P= 0.000 there is a significant difference in the 3 Streptococcus mutans thickness test groups.Conclusion:The probioticLactobacillus casei has the effect of reducing the thickness of the Streptococcus mutans biofilm
The Effect Of Aloe Vera And Manuka Honey On IL-1 Level In Periodontitis Rats Isa Anshori Muchaeroni; Rahmawati Sri Praptiningsih; Anggun Feranisa Feranisa; Brahmadhia Satrio Aziz
Media Dental Intelektual Vol. 7 No. 2 (2025): Media Dental Intelektual August 2025
Publisher : Faculty of Dentistry, Universitas Islam Sultan Agung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30659/medali.7.2.109-114

Abstract

Background: Periodontitis is a chronic inflammatory disease that occurs as a result of the immune system's response to bacterial infection of the gums and surrounding tissues. This condition is caused by chronic inflammation and increased levels of proinflammatory mediators associated with chronic infectious conditions. Periodontitis can trigger inflammation by increasing the level of interleukin-1 (IL-1), which plays a role in the inflammatory response. Aloe vera (Aloe vera) and manuka honey are known to have anti-inflammatory properties and inhibits the production of pro-inflammatory cytokines, including IL-1. Purpose of this research to determine the effect of Aloe Vera and Manuka Honey on IL-1 level in periodontitis rats..Method: 30 rats were randomly divided into four groups; control group, Aloe vera groups, Madu manuka group, combination of Aloe Vera and Manuka Honey group. Aloe vera and Manuka Honey were injected at doses 150 uL in the gingival. At the 5th day after treatment, all rats were terminated and Elisa from gingival tissue was performed to identify the level of IL-1.Result: The results a significant decrease of IL-1 in combination of manuka honey and Aloe Vera group(p<0.000) compared to control groupConclusion: The combination of Aloe Vera and manuka honey significantly decreased on IL-1 level.
Combined Effects Of Aloe Vera And Manuka Honey On IL-6 Level In Periodontitis-Induced Rats Isa Anshori Muchaeroni; Recita Indraswary; Anggun Feranisa; Rahmawati Sri Praptiningsih; Eko Hadianto; Irma Dewi Ratnawati; Nindi Rahmawati Santoso
Media Dental Intelektual Vol. 8 No. 1 (2026): Media Dental Intelektual February 2026
Publisher : Faculty of Dentistry, Universitas Islam Sultan Agung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30659/medali.8.1.25-31

Abstract

ABSTRACTBackground: Periodontitis is a multifactorial inflammatory condition that progressively damages the tooth-supporting structures, including the alveolar bone and periodontal ligament. This process involves a rise in pro-inflammatory cytokines, such as IL-6, which are essential agents in the inflammation and tissue destruction. Aloe vera (Aloe vera) and manuka honey are recognized for their ability to reduce inflammation and suppress the release of pro-inflammatory signaling molecules, such as IL-6. This study aims to evaluate the effectiveness of the combination of Aloe vera and Manuka honey in reducing IL-6 level in periodontitis rats.Method: Thirty rats were randomly assigned to four experimental groups: a control group, Aloe vera group, Manuka Honey group, and a group receiving a combination of Aloe vera and Manuka Honey. The Aloe vera and Manuka Honey treatments were administered via a gingival injection at a dose of 150 uL. After five days treatment, the rats were euthanized. An ELISA (Enzyme-Linked Immunosorbent Assay) was  conducted on the gingival tissue to measure the concentration of Interleukin-6 (IL-6).Result: The combination of Manuka honey and Aloe Vera significantly reduced IL-6 levels compared to the control group (p=0.000).Conclusion: The combination of Aloe Vera and manuka honey are effectively and  significantly reduced on IL-6 level.
Co-Authors Anggun Feranisa Anggun Feranisa Feranisa Brahmadhia Satrio Aziz Eko Hadianto Isa Anshori Muchaeroni Nindi Rahmawati Santoso Rama Putranto Ratnawati, Irma Dewi Recita Indraswary Renanda Rifki Ikhsandarujati Rina Kartika Sari