Article Per Year (5 Year)
p-Index From 2021 - 2026
0.23
P-Index
This Author published in this journals
All Journal Acta Pharmaciae Indonesia : Acta Pharm Indo
Ade Shinta Maria Br Napitu
Department of Pharmacy, Faculty of Science, Institut Teknologi Sumatera, South Lampung 35365, Indonesia
Medicine & Pharmacology

Published : 1 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 1 Documents
Search

 1 
Ethanol extract of cassava (Manihot esculenta Crantz) peel is practically non-toxic after acute oral administration in male ddY mice Ade Shinta Maria Br Napitu; Dewi Damayanti Abdul Karim; Reny Haryani
Acta Pharmaciae Indonesia : Acta Pharm Indo Vol 13 No 2 (2025): Acta Pharmaciae Indonesia: Acta Pharm Indo
Publisher : Pharmacy Department, Faculty of Health Sciences, Jenderal Soedirman University, Purwokerto, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.api.2025.13.2.17067

Abstract

Background: Cassava (Manihot esculenta Crantz) tuber peel contains active compounds with antidiabetic potential, but its safety has not been established. Objective: To evaluate the acute oral toxicity of the ethanol extract of cassava tuber peel, determine its toxicity category, and estimate its LD₅₀ in male ddY mice (Mus musculus). Methods: Male ddY mice (n = 6 per group) received a single oral dose of the extract (1250, 2500, or 5000 mg/kg body weight [BW]) or 1% CMC-Na (control) according to BPOM Regulation No. 10 of 2022. Clinical signs, mortality, body weight, body temperature, and feed and water intake were observed for 14 days, followed by organ index determination. Results: The extract contained flavonoids, saponins, and tannins. No mortality or clinical signs of toxicity occurred at any dose; only transient grooming was observed in all groups, including the control. Body weight, body temperature, feed and water intake, and organ indices did not differ significantly between groups (p > 0.05). Conclusion: The LD₅₀ of the ethanol extract of cassava tuber peel is greater than 5000 mg/kg BW, and the extract is classified as practically non-toxic after a single oral dose.
Co-Authors Dewi Damayanti Abdul Karim Reny Haryani