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All Journal BIOTROPIA - The Southeast Asian Journal of Tropical Biology Biota: Jurnal Ilmiah Ilmu-Ilmu Hayati Jurnal Florea Spizaetus: Jurnal Biologi dan Pendidikan Biologi Makara Journal of Science
Krisnamurti, Gabriella Chandrakirana
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Education Immunology & microbiology Veterinary Other

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Journal : Makara Journal of Science

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Capsaicinoids from Capsicum annuum as an Alternative FabH Inhibitor of Mycobacterium Tuberculosis: In Silico Study Krisnamurti, Gabriella Chandrakirana; Sari, Dewi Ratih Tirto; Bare, Yohanes
Makara Journal of Science Vol. 25, No. 4
Publisher : UI Scholars Hub

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Abstract

The number of tuberculosis (TB) cases worldwide reached 1.5 million in 2018; thus, TB is considered a deadly disease. TB is caused by Mycobacterium tuberculosis and involves lipid synthesis. Considering the importance of lipid metabolism in bacteria, FabH may be an essential protein target for repressing lipid synthesis. Capsaicinoids from Capsicum annuum demonstrate potent antibacterial activity. This study predicted the ability of capsaicinoid compounds to inhibit FabH. In silico analysis was performed by retrieving the structure of FabH from PDB and those of selected capsaicinoid derivatives from PubChem. The compounds were docked using AutoDock Vina in PyRx 0.8 software. The interactions of FabH and different capsaicinoid derivatives showed identical binding characteristics. The bonding type most frequently observed was hydrogen bonds. In conclusion, capsaicinoid derivatives could block lipid synthesis through FabH. The relevant mechanism and biological processes should be studied further.
Co-Authors Bare, Yohanes Budi, Trifan Cicilia Novi Primiani Fajarwati, Mega Agustin Jatmiko Eko Witoyo Putri Susilo, Ananda Sabrina Rahmawati, Salsabela Sari, Dewi Ratih Tirto To'bungan, Nelsiani Ustiatik, Reni Wulan Sari, Adelia Dwi