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All Journal Journal of Food and Pharmaceutical Science Journal of Food and Pharmaceutical Sciences
Melzi Octaviani
Sekolah Tinggi Ilmu Farmasi Riau, Pekanbaru, Riau, Indonesia
Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience

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Subchronic Oral Toxicity of the Ethanol Extract of Crinum asiaticum L. Leaves in Male Rattus norvegicus: Biochemical and Histopathological Evaluation Syilfia Hasti; Aulia Fitri; Melzi Octaviani; Husnawati Husnawati; Ratna Sari Dewi; Gressy Novita; Erniza Pratiwi; Sarah Amelia Azhar; Citra Prameswari; Saskira Windy Noviana; Widya Feranika; Yolanda Selviana Br Bangun; Maya Helmita Mahdar; Fina Aryani; Destiara Adisti; Selin Faysa Satiya
Journal of Food and Pharmaceutical Sciences Vol 14, No 5 (2026): J.Food.Pharm.Sci
Publisher : Integrated Research and Testing Laboratory (LPPT) Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jfps.27539

Abstract

Ethanol extract of Crinum asiaticum L. leaves (CAL) has been reported to possess pharmacological activities and to be suitable for development into a standardised herbal medicine. However, its safety profile remains unknown. This study aimed to evaluate the effects of administering an ethanol extract of CAL leaves at doses of 200, 400, and 800 mg/kgBW on liver, heart, and kidney functions in male Wistar rats (Rattus norvegicus). The test was conducted by repeated oral administration of the ethanol extract over 60 days. The parameters observed included blood biochemistry using a Mindray® BA-88A photometer, gross examination of the heart, and histopathological examination of the liver, heart, and kidney. The conclusion of this study is that repeated oral administration of the ethanol extract of Crinum asiaticum leaves for 60 days did not produce marked alterations in several routine biochemical parameters at the lower doses (200 and 400 mg/kgBW). However, dose-related microscopic and macroscopic changes were observed, particularly at 800 mg/kgBW, and early signs of organ alteration were also noted at intermediate dose levels. Therefore, the extract may be considered to show limited tolerability at lower doses under the present experimental conditions, whereas higher doses indicate potential toxicity to the liver, heart, and kidneys.
Subchronic Oral Toxicity of the Ethanol Extract of Crinum asiaticum L. Leaves in Male Rattus norvegicus: Biochemical and Histopathological Evaluation Syilfia Hasti; Aulia Fitri; Melzi Octaviani; Husnawati Husnawati; Ratna Sari Dewi; Gressy Novita; Erniza Pratiwi; Sarah Amelia Azhar; Citra Prameswari; Saskira Windy Noviana; Widya Feranika; Yolanda Selviana Br Bangun; Maya Helmita Mahdar; Fina Aryani; Destiara Adisti; Selin Faysa Satiya
Journal of Food and Pharmaceutical Sciences Vol 14, No 5 (2026): J.Food.Pharm.Sci
Publisher : Integrated Research and Testing Laboratory (LPPT) Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jfps.27539

Abstract

Ethanol extract of Crinum asiaticum L. leaves (CAL) has been reported to possess pharmacological activities and to be suitable for development into a standardised herbal medicine. However, its safety profile remains unknown. This study aimed to evaluate the effects of administering an ethanol extract of CAL leaves at doses of 200, 400, and 800 mg/kgBW on liver, heart, and kidney functions in male Wistar rats (Rattus norvegicus). The test was conducted by repeated oral administration of the ethanol extract over 60 days. The parameters observed included blood biochemistry using a Mindray® BA-88A photometer, gross examination of the heart, and histopathological examination of the liver, heart, and kidney. The conclusion of this study is that repeated oral administration of the ethanol extract of Crinum asiaticum leaves for 60 days did not produce marked alterations in several routine biochemical parameters at the lower doses (200 and 400 mg/kgBW). However, dose-related microscopic and macroscopic changes were observed, particularly at 800 mg/kgBW, and early signs of organ alteration were also noted at intermediate dose levels. Therefore, the extract may be considered to show limited tolerability at lower doses under the present experimental conditions, whereas higher doses indicate potential toxicity to the liver, heart, and kidneys.
Co-Authors Aulia Fitri Citra Prameswari Destiara Adisti Erniza Pratiwi Fina Aryani Gressy Novita Husnawati Husnawati Maya Helmita Mahdar Ratna Sari Dewi Sarah Amelia Azhar Saskira Windy Noviana Selin Faysa Satiya Syilfia Hasti Widya Feranika Yolanda Selviana Br Bangun