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All Journal Proceeding of International Conference Health, Science And Technology (ICOHETECH)
Najma Nadia Ma’rufah
Universitas Duta Bangsa Surakarta
Computer Science & IT Decision Sciences, Operations Research & Management Health Professions Industrial & Manufacturing Engineering Medicine & Pharmacology

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Natural-Based Mucoadhesive Patch Innovation Using Acorus calamus for Oral Mucosal Wound Healing: A Literature Review Keisya Daniyah Rahma; Najma Nadia Ma’rufah; Kayza Cindy Aulia; Arin Oktaviani Suningdyastiningrum; Fatika Puteri Rosyi Prabowo
Proceeding of the International Conference Health, Science And Technology (ICOHETECH) 2026: Proceeding of the 7th International Conference Health, Science And Technology (ICOHETECH)
Publisher : LPPM Universitas Duta Bangsa Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47701/5m9gys42

Abstract

Oral mucosal wounds are frequently exposed to saliva, mechanical movement, and microbial challenges, which can limit the retention and effectiveness of conventional topical treatments. Mucoadhesive patches offer a potential approach for maintaining local delivery at the wound site, while natural products may provide complementary biological activities. This literature review evaluates the potential of Acorus calamus as a natural active ingredient for an oral mucoadhesive patch intended for mucosal wound healing. Literature published from 2016 to 2026 was identified through PubMed, ScienceDirect, and Google Scholar. Following duplicate removal and eligibility screening, 11 studies were included in the qualitative synthesis. The reviewed evidence indicates that A. calamus exhibits antioxidant, anti-inflammatory, and antibacterial activities, while studies of natural-based mucoadhesive patches demonstrate potential for prolonged mucosal retention, localized delivery, and oral wound management. However, direct evidence combining A. calamus, mucoadhesive patch technology, and oral mucosal wound healing remains limited. Further studies are needed to optimize formulation characteristics, establish safety and stability, and validate wound-healing efficacy using appropriate oral mucosal models. The proposed approach may support the development of a localized and potentially sustainable strategy for oral wound management.
Co-Authors Arin Oktaviani Suningdyastiningrum Fatika Puteri Rosyi Prabowo Kayza Cindy Aulia Keisya Daniyah Rahma