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All Journal Proceeding of International Conference Health, Science And Technology (ICOHETECH)
Kayza Cindy Aulia
Universitas Duta BAngsa Surakarta
Computer Science & IT Decision Sciences, Operations Research & Management Health Professions Industrial & Manufacturing Engineering Medicine & Pharmacology

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ORAL MICROBIOME RECOVERY FOLLOWING ANTIMICROBIAL EXPOSURE: A SCOPING REVIEW OF MICROBIAL RESILIENCE AND RESTORATION OF HOMEOSTASIS Kayza Cindy Aulia; Haura Rasyikha Alhanin; Keisya Daniyah Rahma; Fatika Puteri Rosyi Prabowo; Arin Oktaviani Suningdyastiningrum
Proceeding of the International Conference Health, Science And Technology (ICOHETECH) 2026: Proceeding of the 7th International Conference Health, Science And Technology (ICOHETECH)
Publisher : LPPM Universitas Duta Bangsa Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47701/7xw4sc83

Abstract

The oral microbiome is a dynamic microbial ecosystemthat can be disrupted by antimicrobial exposure, resultingin changes in microbial composition, diversity, andcommunity structure. The capacity of the oral microbiometo withstand environmental disturbances andsubsequently regain ecological stability represents animportant characteristic of microbial resilience and isclosely related to the maintenance of oral microbialhomeostasis. This scoping review aimed to map theavailable evidence regarding oral microbiome responsesfollowing antimicrobial exposure, with particularemphasis on microbial resilience, recovery, andrestoration of homeostasis. Literature was searchedthrough PubMed, ScienceDirect, and Google Scholar usingterms related to oral microbiome, antimicrobial exposure,microbial resilience, and microbial homeostasis. Relevantliterature published within the predefined period wasscreened according to predetermined inclusion andexclusion criteria, followed by data extraction anddescriptive evidence mapping. The findings indicate thatantimicrobial exposure may substantially modify oralmicrobial composition, diversity, community structure,and ecological interactions. Evidence from the includedstudies suggests that oral microbial communities possessvarying degrees of resilience following microbialdisturbance, with recovery influenced by the type andintensity of antimicrobial exposure, characteristics of themicrobial community, and host-related ecological factors.However, the extent and completeness of recovery towardthe pre-exposure state vary across microbialcommunities and exposure conditions. These findingshighlight the importance of understanding oralmicrobiome resilience and recovery as key processes in the restoration and maintenance of oral microbialhomeostasis and provide a basis for further longitudinalresearch on strategies to preserve microbial stabilityfollowing antimicrobial disturbance.
Natural-Based Mucoadhesive Patch Innovation Using Acorus calamus for Oral Mucosal Wound Healing: A Literature Review Keisya Daniyah Rahma; Najma Nadia Ma’rufah; Kayza Cindy Aulia; Arin Oktaviani Suningdyastiningrum; Fatika Puteri Rosyi Prabowo
Proceeding of the International Conference Health, Science And Technology (ICOHETECH) 2026: Proceeding of the 7th International Conference Health, Science And Technology (ICOHETECH)
Publisher : LPPM Universitas Duta Bangsa Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47701/5m9gys42

Abstract

Oral mucosal wounds are frequently exposed to saliva, mechanical movement, and microbial challenges, which can limit the retention and effectiveness of conventional topical treatments. Mucoadhesive patches offer a potential approach for maintaining local delivery at the wound site, while natural products may provide complementary biological activities. This literature review evaluates the potential of Acorus calamus as a natural active ingredient for an oral mucoadhesive patch intended for mucosal wound healing. Literature published from 2016 to 2026 was identified through PubMed, ScienceDirect, and Google Scholar. Following duplicate removal and eligibility screening, 11 studies were included in the qualitative synthesis. The reviewed evidence indicates that A. calamus exhibits antioxidant, anti-inflammatory, and antibacterial activities, while studies of natural-based mucoadhesive patches demonstrate potential for prolonged mucosal retention, localized delivery, and oral wound management. However, direct evidence combining A. calamus, mucoadhesive patch technology, and oral mucosal wound healing remains limited. Further studies are needed to optimize formulation characteristics, establish safety and stability, and validate wound-healing efficacy using appropriate oral mucosal models. The proposed approach may support the development of a localized and potentially sustainable strategy for oral wound management.
Co-Authors Arin Oktaviani Suningdyastiningrum Fatika Puteri Rosyi Prabowo Haura Rasyikha Alhanin Keisya Daniyah Rahma Najma Nadia Ma’rufah