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All Journal Obat: Jurnal Riset Ilmu Farmasi dan Kesehatan
Tris Ella Julita Gulo
Sekolah Tinggi Ilmu Kesehatan Bogor Husada
Health Professions Nursing Public Health

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Identifikasi Drug Related Problem (DRPs) Kategori Ketepatan Obat, Kesesuaian Dosis, dan Interaksi Obat pada Pasien Diabetes Mellitus Tipe 2 dengan Komorbiditas Hipertensi di Rumah Sakit FMC Bogor Tahun 2024–2025 Tris Ella Julita Gulo; Rahmadhani Tyas Angganawati; Ilham Maulana
OBAT: Jurnal Riset Ilmu Farmasi dan Kesehatan Vol. 4 No. 6 (2026): November: OBAT: Jurnal Riset Ilmu Farmasi dan Kesehatan
Publisher : Asosiasi Riset Ilmu Kesehatan Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61132/obat.v4i6.2538

Abstract

This study aimed to analyze the incidence profile of DRPs in the categories of drug appropriateness, dose suitability, and drug interactions in type 2 diabetes patients with hypertension comorbidity at FMC Bogor Hospital in 2024–2025. This was a non-experimental study with a descriptive design and retrospective data collection using medical records. The sample consisted of 72 patients who met the inclusion criteria, selected through total sampling, and the data were analyzed descriptively. The results showed that DRPs in the drug appropriateness category were found in 7 patients (9.72%), comprising 6 patients who had an indication but did not receive therapy and 1 patient who experienced duplicate medication therapy. DRPs in the dose suitability category were found in 4 patients (5.55%), all of whom received antihypertensive medications below the therapeutic dose. Drug interactions were identified in 68 patients (94.44%), with moderate-level interactions being the most common severity, accounting for 201 cases (80.08%). Based on the mechanism, pharmacodynamic interactions were more dominant, with 190 cases (75.69%), compared with pharmacokinetic interactions at 61 cases (24.30%). These findings imply the need for closer monitoring of drug therapy to improve patient safety and treatment outcomes.
Co-Authors Ilham Maulana Rahmadhani Tyas Angganawati