Alyauma Akmal Kalani
Meuraxa Hospital, Banda Aceh

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Association Between HbA1c Levels and Pain Intensity in Diabetic Peripheral Neuropathy: A Narrative Review Juwita Juwita; Nanda Ayu Puspita; Sakdiah Sakdiah; Cut Gina Inggriyani; Hijra Novia Suardi; Hafni Andayani; Alyauma Akmal Kalani
Asian Journal of Natural Sciences Vol. 5 No. 3 (2026): August 2026
Publisher : Asian Journal of Natural Sciences

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55927/ajns.v5i3.6

Abstract

Diabetic peripheral neuropathy (DPN) can impair physical function and reduce quality of life. Although HbA1c reflects glycaemic exposure, its relationship with neuropathic pain severity remains unclear. This narrative review found that higher HbA1c levels, indicating poorer glycaemic control, were generally associated with DPN and painful diabetic peripheral neuropathy (PDPN). Several studies reported a higher prevalence of PDPN among patients with elevated HbA1c, although evidence regarding pain intensity was limited and associations were modest. Neuropathic pain was also influenced by diabetes duration, obesity, dyslipidaemia, and metabolic syndrome. Furthermore, rapid reductions in HbA1c were associated with treatment-induced neuropathy, suggesting a potentially nonlinear relationship between glycaemic control and neuropathic pain.