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Uji aktivitas Madu Seulawah sebagai antibakteri dalam menghambat pertumbuhan Pseudomonas aeruginosa ATCC 27853 Fadhil Malik; Suryawati Suryawati; Wilda Mahdani; Hijra Novia Suardi
Jurnal Bioleuser VOL 3, NO 1 (2019): April 2019
Publisher : Department of Biology, Faculty of Mathematics and Natural Sciences, University of Syiah Ku

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24815/j. bioleuser.v0i0.18809

Pseudomonas aeruginosa memiliki berbagai faktor virulensi yang berfungsi untuk menghindar dari sistem pertahanan tubuh manusia, membentuk koloni dan menimbulkan penyakit infeksi. Pseudomonas aeruginosa termasuk patogen yang sulit diobati. Resistensinya terhadap beberapa antibiotik seringkali menyebabkan kegagalan pengobatan sehingga sering dikaitkan dengan penyebab utama kematian. Pengobatan dari bahan alam dinilai memiliki efek samping yang minimal dibandingkan dengan obat yang berasal dari bahan kimia. Salah satu bahan alami yang memiliki kandungan sebagai antibakteri ialah madu. Untuk mengetahui aktivitas antibakteri madu Seulawah terhadap pertumbuhan Pseudomonas aeruginosa digunakan metode difusi cakram. Penelitian ini merupakan penelitian eksperimental dengan menggunakan metode rancangan acak lengkap yang terdiri dari enam kelompok perlakuan dan empat kali pengulangan. Kelompok perlakuan menggunakan akuades sebagai kontrol negatif, seftazidim 30µg sebagai kontrol positif, dan madu Seulawah dengan konsentrasi 25%, 50%, 75%, dan 100%. Data penelitian dianalisis menggunakan analisis komparasi. Hasil penelitian ini menunjukkan madu Seulawah dengan konsentrasi 25%, 50%, 75%, dan 100% memiliki rata-rata daya hambat pada masing-masing konsentrasi sebesar 6,89 mm, 7,23 mm, 7,45 mm, dan 7,54 mm. Berdasarkan kriteria Morales, daya hambat madu Seulawah terhadap pertumbuhan Pseudomonas aeruginosa tergolong hambatan yang lemah. Uji statistik menunjukkan mean rank pada konsentrasi 75% dan 100% memiliki kesamaan ranking sehingga tidak ada konsentrasi optimum madu Seulawah yang paling efektif dalam menghambat pertumbuhan Pseudomonas aeruginosa.

Hubungan tingkat pengetahuan dengan sikap terhadap imunisasi vaksin Human Papilloma Virus sebagai pencegahan primer kanker serviks pada mahasiswi fakultas keperawatan Unsyiah Vera Dewi Mulia; Nurrahmah Latifa; Mirfandi Amirsyah; Hijra Suardi Novia
Jurnal Kedokteran Syiah Kuala Vol 21, No 3 (2021): Volume 21 Nomor 3 Desember 2021
Publisher : Universitas Syiah Kuala

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24815/jks.v21i3.23857

Abstrak. Kanker serviks merupakan silent killer disease dengan penderita risiko tinggi pada perempuan mulai umur 20 tahun. Human Papilloma Virus (HPV) adalah penyebab terjadinya kanker serviks. Kanker serviks dapat dicegah secara efektif dengan vaksinasi HPV. Penelitian ini bertujuan untuk mengetahui hubungan antara tingkat pengetahuan dengan sikap terhadap imunisasi vaksin HPV sebagai pencegahan primer kanker serviks pada Mahasiswi Fakultas Keperawatan Unsyiah. Penelitian ini merupakan penelitian observasional analitik dengan desain cross sectional. Sampel penelitian adalah 82 Mahasiswi Fakultas Keperawatan Unsyiah. Pemilihan sampel menggunakan teknik proportional random sampling. Pengambilan data dilakukan dengan mengisi kuisioner online (google form). Uji hipotesis yang digunakan adalah fisher exact test. Hasil penelitian menunjukkan bahwa sebanyak 41 Mahasiswi (50.0%) memiliki tingkat pengetahuan baik dan sikap positif terhadap imunisasi vaksin HPV sebanyak 78 Mahasiswi (95.1%). Hasil uji statistik fisher exact test diperoleh p-value sebesar 0.000 (p 0.05), sehingga H0 ditolak. Kesimpulan yang diperoleh adalah terdapat hubungan tingkat pengetahuan dengan sikap terhadap imunisasi vaksin HPV sebagai pencegahan primer kanker serviks pada Mahasiswi Fakultas Keperawatan Unsyiah. Kata kunci: Pengetahuan, sikap, imunisasi vaksin HPV, mahasiswi Abstract. Cervical cancer is the silent killer disease with high risk patients in women starting at 20 years old. Human Papilloma Virus (HPV) is known as precursor of cervical cancer. Cervical cancer can be prevented effectively by practicing HPV vaccine. The purpose of this study was to determine the relationship between knowledge and attitude toward HPV vaccination as primary prevention of cervical cancer for student in Nursing Faculty of Syiah Kuala University. This research is an observational analytic study with cross sectional design. The sample of this research are students in Nursing Faculty of Syiah Kuala University with the quantity of 82 students taken by using proportional random smapling technique. The data was collected by filling out an online questionnaire (google form). The hypothesis in this study was analyzed by fisher exact test. The results showed that there was 41 college student (50.0%) had a good of knowledge and positive attitude about HPV vaccination there was 78 college students (95.1%). Fisher exact test statistic test result obtained p-value was 0.000 (p 0.05), so H0 was rejected. The conclusion is there was a relationship between knowledge and attitude toward HPV vaccination as primary prevention of cervical cancer for students in Nursing Faculty of Syiah Kuala University. Keywords: Knowledge, attitude, HPV vaccination immunization, college student

Interaksi obat potensial pada pasien usia lanjut Hijra Novia Suardi; Suryawati Suryawati; Vera Dewi Mulia
Jurnal Kedokteran Syiah Kuala Vol 21, No 1 (2021): Volume 21 Nomor 1 April 2021
Publisher : Universitas Syiah Kuala

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24815/jks.v21i1.21272

Interaksi obat beresiko terjadi pada kelompok usia lanjut karena penggunaan jumlah obat yang banyak (polifarmasi). Resiko interaksi obat ini dapat meningkat karena perubahan anatomi dan fisiologi tubuh yang menyebabkan penurunan fungsi dari organ yang terlibat dalam proses absorpsi, metabolisme, distribusi dan ekskresi obat. Artikel ini memaparkan beberapa interaksi obat potensial akibat penggunaan lebih dari satu obat pada saat yang bersamaan. Interaksi obat tersebut meliput penggunaan warfarin, ACE-inhibitor dan Digoksin.

Survey Of The Cardiovascular Drug Interactions On Geriatrics At Internal Medicine Ward Of RSUDZA Banda Aceh Hijra Novia Suardi; Suryawati Suryawati
Proceedings of The Annual International Conference, Syiah Kuala University - Life Sciences & Engineering Chapter Vol 5, No 2 (2015): Life Sciences
Publisher : Syiah Kuala University

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The increase of elderly population in Indonesia leads to the drug misuse. The physiological change in geriatric become the major reason. It affects the change of drug’s pharmacodynamic, pharmacokinetics and the harmful drug interaction among overly prescribed medication. Cardiovascular drugs produce the most common side effect in elderly patient. This study aims to observe the accuracy of cardiovascular drugs used based on its dose and drug interaction. The subject of this study are the 60 years old-or more- inpatients in Rumah Sakit Umum Zainoel Abidin’s (RSUDZA) Internal medicine ward who received cardiovascular drugs prescription. The data were collected from medical record and nurse’s drugs record. The analysis were performed descriptively by evaluate the drug interaction theoritically based on literature study and available concensuses. The result shows that the Potential interaction occurred in 75 ( 68.18 % ) of cardiovascular drug used, and 22 (20 %) of whom are important potential interactions. The most frequent drugs that have the potential interaction in this study are furosemide , spironolactone, captopril, digoxin and aspirin

The potential antioxidant activity of ethanolic extract of Aceh ant-plant (Mymercodia sp) on the free radical DPPH(1,1-Diphenyl-2-pikrylhidrazil) . Suryawati; . Frengki; Hijra Novia Suardi
Proceedings of The Annual International Conference, Syiah Kuala University - Life Sciences & Engineering Chapter Vol 3, No 1 (2013): Life Sciences
Publisher : Syiah Kuala University

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This research aims to investigate the potential antioxidant activity of ethanolic extract of Aceh ant-plant (Mymercodia sp) on the free radical DPPH (1,1-diphenyl-2-pikrylhidrazyl). The ant-plant was extracted using maceration technique with the ethanol as solvent. The extract was made in various concentrations: 5, 10, 25, and 50 ppm. Then DPPH solution was added to it. Absorbance reading was conducted with spectrophotometry at the wave length of 517 nm after 30 minutes. The result of research shows the potency of ant-plant (Mymercodia sp) as an antioxidant free radical scavenging ethanolic extract with IC50 value of 14.73 ppm. The ascorbic acid as the control showed IC50 value of 7:32 ppm.

The use of herbal medicine in children Suryawati Suryawati; Hijra Novia Suardi
Proceedings of The Annual International Conference, Syiah Kuala University - Life Sciences & Engineering Chapter Vol 5, No 2 (2015): Life Sciences
Publisher : Syiah Kuala University

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (374.719 KB)

The herbal medicine has been widely used in children for the treatment of several symptoms and the prevention of diseases before accessing the hospital for professionals help. There are 3 kinds of marketed herbal medicine including empirical based herbal medicine (jamu), standardized herbal medicine (obat herbal terstandar) and clininically tested herbal medicine (fitofarmaka). This study aimed to investigate the utilization of the marketed herbal medicine along with non marketed ones which was known as the Indonesian original herbal medicine (Obat Asli Indonesia, OAI) in children. The cross sectional study was conducted by interviewing 91 parents whose children were hospitalized in RSUD Meuraxa, Banda Aceh. The interview was conducted using a structured questionnaire from 4 to 29 September 2014. The result showed that the Indonesian original herbal medicine was used most frequently followed by herbal (jamu), standardized herbal and clininically tested herbal medicine. The utilization of herbal medicine was associated with the knowledge of parents and did not correlate to their economic level. All of the parents did not know the side effects of herbal medicine to their children’s body and few of them knew the indication of herbal remedies. Overall, it was concluded that eventhough the knowledge of parents about the safety and activity of herbal medicine was not sufficient the use of herbal medicine in children was common

Pengetahuan dan sikap tentang penggunaan herbal oleh geriatri di Banda Aceh Auzan Al Kautsar; vera dewi mulia; Suryawati Suryawati; Hafni Andayani; Nichola Anti Perdana; Hijra Novia Suardi; zahratul aini
Jurnal Kedokteran Syiah Kuala Vol 22, No 1 (2022): Volume 22 Nomor 1 Maret 2022
Publisher : Universitas Syiah Kuala

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24815/jks.v22i1.23882

Peningkatan penggunaan produk obat herbal terutama pada lansia menimbulkan kekhawatiran akan keamanannya. Tujuan dari penelitian ini adalah untuk mensurvei penggunaan obat herbal lansia sehingga dapat dipantau penggunaannya. Penelitian ini merupakan studi observasional dengan desain potong-lintang pada pasien usia lanjut (≥60 tahun) yang berobat di sepuluh puskesmas di Banda Aceh. Pengambilan data dilakukan melalui wawancara terpimpin menggunakan kuesioner. Sebanyak 294 responden tergabung dalam penelitian ini. Hasil yang didapatkan menunjukkan bahwa 40% responden menggunakan tanaman obat herbal daripada resep dokter, 49% responden mengakui bahwa resep dokter belum tentu lebih mahal daripada tanaman obat herbal, 56% responden percaya bahwa obat herbal mempunyai efek lebih baik daripada resep dokter. Sejumlah responden sudah teredukasi terkait tanaman obat herbal, dimana 48% responden tidak setuju bila tanaman obat herbal dapat dikonsumsi tanpa batasan dosis, dan 67% responden menyebutkan tidak semua tanaman obat herbal terbukti ilmiah dapat mengobati penyakit. Berdasarkan pengakuan responden didapatkan bahwa 66% responden setuju bahwa penggunaan tanaman obat herbal tetap memerlukan obat resep dokter dan 67% responden merasa perlu memberitahukan dokter tentang tanaman obat herbal yang digunakan. Kesimpulan dalam penelitian ini bahwa pasien geriatri dengan penyakit degeneratif dan kronis yang menggunakan obat herbal sudah teredukasi

Acute toxicity evaluation of ethanolic extract of the leaves of Anredera cordifolia in wistar rats (Rattus Norvegicus) SURYAWATI SURYAWATI; NISSA SEURUNIE; DAMAR DITA KIRANA; VERA DEWI MULIA; HIJRA NOVIA SUARDI
Jurnal Natural Volume 22 Number 2, June 2022
Publisher : Universitas Syiah Kuala

Anredera cordifolia (Binahong) is one of the medicinal plants that has been widely used for its properties of inhibiting the growth of microorganisms, decreasing blood uric acid, and healing wounds. This study was conducted to evaluate the acute toxicity effects of ethanolic extract of binahong to support its use as a medicinal plant. Ethanolic extracts of binahong leaves were prepared. Twenty-five white male rats (Rattus norvegicus) were divided into 5 groups and administered with a single dose of Na-CMC suspension or a dose of 300, 600, 1200, or 2400 mg/kg BW of binahong ethanolic leaf extract, respectively. Toxicity symptoms were monitored at three-time intervals: ½-1, 1½-2, and 3-6 hours after the administration. A macroscopic evaluation of the rat’s liver was carried out to identify any lesion. The rat’s liver and whole-body weights were determined to assess the weight reduction. The results showed that there was no dead rat in any of the groups, indicating that no LD50 was identified. Also, there were several toxic effects observed including a decrease in movements, somatic response, insensitivity, and stool consistency. There was no evidence of a lesion on liver macroscopy. However, the weights of rats’ livers increased in tandem with the reduction in their body weights. The findings from this study reveal that single dose of binahong ethanolic extract ranging from 300 to 2400 mg/kg BW are safe, while minimal toxic effects were observed.

Antibiotik Dalam Dunia Kedokteran Gigi Hijra Novia Suardi
Cakradonya Dental Journal Vol 6, No 2 (2014): Desember 2014
Publisher : FKG Unsyiah

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (371.644 KB)

Antibiotik dalam bidang kedokteran gigi sangat luas digunakan baik untuk pengobatan infeksi (terapeutik) ataupun dengan tujuan profilaksis penyakit infeksi. Antibiotik yang banyak digunakan dalam bidang kedokteran gigi adalah golongan penisilin seperti penisilin dan amoksisilin, makrolida seperti klindamisin, golongan sefalosporin dan metronidazol. Hal ini sesuai dengan jenis bakteri yang sering menyebabkan infeksi odontogenik, yaitu bakteri Gram positif dan bakteri anaerob. Tingkat penggunaan antibiotik secara empiris yang tinggi menimbulkan berbagai permasalahan sehingga dapat menyebabkan penggunaan antibiotik yang tidak rasional. Pemilihan antibiotik dan penyesuaian dosis obat harus dilakukan secara cermat dan tepat pada pasien-pasien khusus yang mengalami perubahan farmakokinetik dan farmakodinamik, diantaranya pasien anak-anak dan usia lanjut, pasien dengan gangguan fungsi ginjal dan/ atau hati, serta pasien wanita yang sedang hamil atau menyusui. Insiden terjadinya resistensi terhadap antibiotik mulai terjadi peningkatan di berbagai bidang kesehatan belakangan ini, termasuk kedokteran gigi sehingga diperlukan perhatian khusus termasuk dari para dokter gigi untuk menekan kejadian ini dengan menggunakan antibiotik secara tepat dan benar.

Acute toxicity evaluation of ethanolic extract of the leaves of Anredera cordifolia in wistar rats (Rattus Norvegicus) SURYAWATI SURYAWATI; NISSA SEURUNIE; DAMAR DITA KIRANA; VERA DEWI MULIA; HIJRA NOVIA SUARDI
Jurnal Natural Volume 22 Number 2, June 2022
Publisher : Universitas Syiah Kuala

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24815/jn.v22i2.22285

Anredera cordifolia (Binahong) is one of the medicinal plants that has been widely used for its properties of inhibiting the growth of microorganisms, decreasing blood uric acid, and healing wounds. This study was conducted to evaluate the acute toxicity effects of ethanolic extract of binahong to support its use as a medicinal plant. Ethanolic extracts of binahong leaves were prepared. Twenty-five white male rats (Rattus norvegicus) were divided into 5 groups and administered with a single dose of Na-CMC suspension or a dose of 300, 600, 1200, or 2400 mg/kg BW of binahong ethanolic leaf extract, respectively. Toxicity symptoms were monitored at three-time intervals: ½-1, 1½-2, and 3-6 hours after the administration. A macroscopic evaluation of the rat’s liver was carried out to identify any lesion. The rat’s liver and whole-body weights were determined to assess the weight reduction. The results showed that there was no dead rat in any of the groups, indicating that no LD50 was identified. Also, there were several toxic effects observed including a decrease in movements, somatic response, insensitivity, and stool consistency. There was no evidence of a lesion on liver macroscopy. However, the weights of rats’ livers increased in tandem with the reduction in their body weights. The findings from this study reveal that single dose of binahong ethanolic extract ranging from 300 to 2400 mg/kg BW are safe, while minimal toxic effects were observed.

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