<![CDATA[Human Immunodeficiency Virus (HIV) remains a significant public health problem in Indonesia, with approximately 660,000 people reported as living with the infection. This case report aims to describe the clinical diagnosis of HIV stage 4, supporting laboratory examinations, and the opportunistic complications associated with advanced disease progression. The patient presented with severe clinical manifestations consistent with wasting syndrome, including prolonged diarrhea lasting more than one month accompanied by blood, generalized weakness, and a bedridden condition accounting for more than 50% of daily activity. Additional findings included oral candidiasis, generalized pruritus, a history of tuberculosis infection, and previous diagnosis of B20 (+), along with hypoalbuminemia indicating severe nutritional deficiency. Laboratory evaluation demonstrated a significant reduction in CD4+ T-cell counts, confirming advanced immunosuppression. Patients in stage 4 HIV are highly vulnerable to multiple opportunistic infections and metabolic complications, such as tuberculosis reactivation, candidiasis, hyponatremia, hypokalemia, and severe hypoalbuminemia. Management of stage 4 HIV requires a comprehensive therapeutic approach, including treatment of active opportunistic infections, prevention of recurrent infections, nutritional support, and strengthening of immune function through antiretroviral therapy. Early recognition and integrated management are essential to improve patient outcomes and reduce mortality in advanced HIV cases.]]>
