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All Journal JURNAL FARMASIMED (JFM)
Ernawatty Ginting
Universitas Tjut nyak Dien
Medicine & Pharmacology

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Formulation and Evaluation of an Anti-Acne Toner Preparation Containing Red palm oil (Red palm oil) for Antibacterial Activity Against Propionibacterium acnes Shahira Yasmin; Ernawatty Ginting; Kanne Dachi; Sudewi
Jurnal FARMASIMED (JFM) Vol 9 No 1 (2026): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/jfm.v9i1.3915

Abstract

Background: Acne is a common skin disorder associated with the growth of Propionibacterium acnes. Red palm oil derived from the fruit contains bioactive compounds with potential antibacterial properties, making it a promising active ingredient for anti-acne toner formulations. Aim: to develop an anti-acne toner containing Red palm oil, evaluate its physical characteristics, and determine its antibacterial activity against Propionibacterium acnes. Methods: This study was an experimental laboratory research using a quantitative approach. Four formulations were prepared, namely F0 (base), F1 (1%), F2 (3%), and F3 (5%) Red palm oil. The formulations were evaluated for organoleptic properties, homogeneity, pH, adhesion, stability using the cycling test, skin irritation, and hedonic acceptance. Antibacterial activity was determined using the disc diffusion method. Results: In conclusion, Red palm oil derived from the fruit can be successfully formulated into an anti-acne toner that meets the required physical evaluation parameters, is stable and safe for use, and exhibits antibacterial activity against Propionibacterium acnes. In conclusion, red palm oil derived from the fruit can be successfully formulated into an anti-acne toner that meets the required physical evaluation parameters, is stable and safe for use, and exhibits antibacterial activity against Propionibacterium acnes.
Utilization of Corn Cob Hemicellulose in Swelling Tablet Formulations as a Novel Approach of Dietary Therapy Ernawatty Ginting; Ali Affan Silalahi; Putra Chandra
Jurnal FARMASIMED (JFM) Vol 9 No 1 (2026): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/jfm.v9i1.4075

Abstract

Background: Obesity is a growing global public health concern that requires safe, effective, and sustainable approaches to support weight management. Natural polysaccharides, particularly hemicellulose derived from agricultural waste, offer promising potential for developing swelling tablets due to their hydrophilic properties and ability to form polymeric matrices. Objective: This study aimed to formulate and characterize corn cob hemicellulose-based swelling tablets using chitosan, polyvinyl alcohol (PVA), and crosslinking components. Methods: This experimental study involved corn cob preparation, delignification, hemicellulose extraction, tablet formulation, and physicochemical characterization using Fourier-transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM), and X-ray diffraction (XRD). Results: The isolated hemicellulose was obtained as a white powder with a yield below 20%. Characterization indicated polymer-network formation, porous morphology, and distinct XRD diffraction features. Chitosan–PVA and chitosan PVA STPP formulations produced visually intact tablets that exhibited swelling while maintaining structural integrity for 2 4 hours. Conclusion: Corn cob hemicellulose demonstrates potential as a renewable polymeric material for developing swelling tablets. However, further quantitative evaluation of swelling capacity, mechanical properties, and safety is required to establish its suitability for weight management applications.
Co-Authors Ali Affan Silalahi Kanne Dachi Putra Chandra Shahira Yasmin Sudewi