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All Journal Indonesian Journal of Pharmaceutical Science and Technology
Aisyah, Oktalia Nurul
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Computer Science & IT Medicine & Pharmacology

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Nanocurcumin Mediated Modulation of Apoptotic Pathways in Cervical Cancer: A Systematic Review Savira, Wandha Okta; Subandi, Subandi; Permatasari, Happy Kurnia; Lestari, Bayu; Aisyah, Oktalia Nurul
Indonesian Journal of Pharmaceutical Science and Technology Vol 13, No 2 (2026)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v13i2.71396

Abstract

Cervical cancer is the fourth most common malignancy in women, driven largely by HPV oncoproteins E6 and E7, which degrade the tumor suppressors p53 and retinoblastoma protein and blunt apoptosis. Curcumin is pro-apoptotic but clinically limited by poor solubility, instability, and low bioavailability, motivating nanoformulation. This systematic review evaluated the apoptotic mechanisms, physicochemical characteristics, and preclinical efficacy of nanocurcumin in cervical cancer. Following PRISMA 2020, four databases (PubMed, Scopus, ScienceDirect, SpringerLink) were searched; 16 preclinical studies (2015–2025) met eligibility from 1,604 records. Nanocurcumin induced apoptosis through four convergent mechanisms: the intrinsic mitochondrial pathway (Bax/Bcl-2 modulation, caspase activation), ROS-mediated oxidative stress, suppression of HPV E6/E7 with restoration of p53 and Rb, and inhibition of PI3K/AKT/mTOR and NF-κB signaling. Formulations ranged from ~52 to 390 nm with encapsulation efficiencies often above 85%; folate receptor–mediated targeting gave the most reproducible uptake gains. Combination strategies consistently outperformed monotherapy in vivo, including extended survival. However, the near-absence of systemic pharmacokinetic and long-term toxicity data, non-representative models, and scalability challenges indicate that substantial development is needed before clinical evaluation.
Co-Authors Happy Kurnia Permatasari Lestari, Bayu Savira, Wandha Okta Subandi Subandi