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All Journal Dentika Dental Journal Jurnal Penelitian Pendidikan IPA (JPPIPA) International Journal of Science and Society (IJSOC) JKKI : Jurnal Kedokteran dan Kesehatan Indonesia Junior Medical Journal Cerdika: Jurnal Ilmiah Indonesia
Harliansyah
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Religion Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Dentistry Economics, Econometrics & Finance Education Health Professions Materials Science & Nanotechnology Medicine & Pharmacology Physics Public Health Social Sciences

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DISCOLORATION OF TOOTH ENAMEL DUE TO BETEL LEAF EXTRACT (Piper betle Linn): DISKOLORISASI EMAIL GIGI AKIBAT EKSTRAK DAUN SIRIH (Piper betle Linn) Mustaqimah, Dewi Nurul; Harliansyah; Hannisa, Muthia
Dentika: Dental Journal Vol. 21 No. 01 (2018): Dentika Dental Journal
Publisher : TALENTA

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (333.103 KB) | DOI: 10.32734/dentika.v21i01.196

Abstract

The tooth enamel colour play an important role in esthetics. The discoloured teeth could be due to the using of boild Piper betle extract as a mouth wash. Up to now many people in Indonesia using the boiling Piper betle extract to manage oral diseases and to prevent tooth decay. The aim of this in vitro study are to know the effective concentration and application time of this agent to change the enamel colour. Fresh Piper betle leaves were processed to get 4 differents concentration (50, 33, 25, and 5%). Aquabidest was used as negative control. Every concentration was studyed using 2 maxillae premolar teeth in 24, 48, and 72 hours application times. 30 good condition teeth were used in this research. The results showed that every concentration gaves discoloured changes. The optimal concentration and duration are 25% and 48 hours. It is concluded that using of this gargling agent must be intermittent. It can be suggested to use this agent only once or twice daily, each for 2 until 3 minutes gargling.
Analisis Oxidation Reduction Potential (ORP) dan Kadar Alkohol dalam Wortel (Daucus Carota L) dan Tinjaunnya Menurut Pandangan Islam Putriwangi, Awalia syahra; Harliansyah; Mahmud, Amir
Junior Medical Journal Vol. 2 No. 8 (2024): April 2024
Publisher : Fakultas Kedokteran Universitas YARSI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33476/jmj.v2i8.4242

Abstract

Wortel (Daucus carota L.) merupakan sayuran yang mudah ditemui dan digemari masyarakat Indonesia sebagai bahan untuk membuat aneka macam masakan serta memiliki banyak manfaat dalam menjaga kesehatan. Oxidation Reduction Potential (ORP) merupakan index untuk mengukur tingkat oksidasi dan reduksi yang menggambarkan adanya mekanisme transfer elektron dari suatu ion ke ion lain. Alkohol merupakan hasil yang dapat diperoleh dari penyimpanan dalam kondisi anaerob. Penelitian ini merupakan penelitian eksperimental laboratorium dengan menguji nilai ORP dan kadar alkohol dalam wortel (Daucus carota L.). Nilai ORP diukur dengan menggunakan alat ORP meter dan kadar alkohol menggunakan Gas Chromatography-Mass Spectometry (GC-MS). Analisis data didapatkan dengan uji Anova menggunakan IBM SPSS Statistics 25. Hasil penelitian menunjukkan bahwa terdapat pengaruh lama penyimpanan 0; 1; 2; 3; dan 4 hari terhadap nilai ORP dan kadar alkohol. Nilai ORP yang didapatkan berturut-turut untuk 0 hari 16±4.58; 0.33±0.58; (-8.67)±3.08; (-17.33)±1.52; dan (-28.33)±3.51 (mV). Sedangkan kadar alkohol didapatkan berturut-turut 0; 0.05±0.002; 0.19±0.000; 0.24±0.01; dan 0.05±0.003 (%). Semakin lama waktu penyimpanan maka nilai ORP wortel akan semakin rendah dan kadar alkohol akan naik mencapai titik tertentu dan kemudian turun. Hal ini diduga alkohol sudah mengalami oksidasi menjadi asam. Carrots (Daucus carota L.) are vegetables that are easily found and favored by the people of Indonesia as an ingredient to make various kinds of dishes and have many benefits in maintaining health. Oxidation Reduction Potential (ORP) is an index to measure the degree of oxidation and reduction that describes the mechanism of electron transfer from one ion to another. Alcohol is a result that can be obtained from storage under anaerobic conditions. This study is a laboratory experimental study by testing the value of ORP and alcohol content in carrots (Daucus carota L.). The ORP value is measured using an ORP meter and alcohol content using Gas Chromatography-Mass Spectometry (GC-MS). Data analysis was obtained by Anova test using IBM SPSS Statistics 25. The results showed that there was an effect of storage duration 0; 1; 2; 3; and 4 days against ORP values and alcohol levels. ORP value obtained consecutively for 0 days 16±4.58; 0.33±0.58; (-8.67)±3.08; (-17.33)±1.52; and (-28.33)±3.51 (mV). While the alcohol content was obtained consecutively 0; 0.05±0.002; 0.19±0.000; 0.24±0.01; and 0.05±0.003 (%). The longer the storage time, the lower the carrot ORP value will be and the alcohol content will rise to a certain point and then go down. It is suspected that alcohol has undergone oxidation to acid.
The Effect of Moringa Oleifera Extract on Melatonin Levels and Skin Cell Images in Rattus Novergicus Exposed to Ultraviolet Rays Rosalina, Irma; Harliansyah; Kusumawaty, Ira
Jurnal Penelitian Pendidikan IPA Vol 11 No 7 (2025): July
Publisher : Postgraduate, University of Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jppipa.v11i7.11298

Abstract

Exposure to ultraviolet (UV) light has negative effects on skin health, including decreased melatonin levels and increased skin cell damage. This study investigated the effects of Moringa oleifera (MO) leaf extract on melatonin levels and skin damage induced by UVB light in male Sprague Dawley rats. Utilizing a post-randomized controlled group design, 28 rats were allocated into four groups: a control group without treatment and a treatment group subjected to UVB exposure alongside MO extract at doses of 300 mg/kg and 600 mg/kg. Melatonin levels were quantitatively assessed via spectrophotometry, while histopathological analysis was employed to evaluate skin damage. Results indicated that rats receiving the 600 mg/kg MO extract exhibited the highest melatonin levels, contrasting sharply with the group exposed solely to UVB radiation, which showed significantly reduced melatonin. Histological examination revealed a marked decrease in sunburn cell lesions in the MO extract-treated group compared to the control group lacking treatment. In conclusion, Moringa oleifera leaf extract appears to enhance melatonin production and mitigate UV-induced skin damage, suggesting its potential as a protective agent in dermatological practices. These findings warrant further exploration into the application of MO extract in developing preventive therapies against UV-related skin damage.
Sleep Pattern Factors on Premature Skin Aging in YARSI University Medical Students, Force of 2021 Aprilia, Dhea; Harliansyah; Lilis, Nenden
International Journal of Science and Society Vol 6 No 1 (2024): International Journal of Science and Society (IJSOC)
Publisher : GoAcademica Research & Publishing

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.54783/ijsoc.v6i1.997

Abstract

Skin aging does not only occur in older people, but skin aging can appear when entering early adulthood or is called premature skin aging. Skin problems such as the appearance of wrinkles and fine lines on the face, apart from that hyperpigmentation can also occur and large pores, are signs of premature skin aging. Lifestyle factors greatly influence the occurrence of premature skin aging, one of which is poor sleep patterns with poor sleep quality. This study aims to test and show the relationship between sleep patterns and premature skin. Quantitative research methods were applied in this research. The research population was students from the Faculty of Medicine, YARSI University Class of 2021, aged 20-25 years. Data collection methods used questionnaires and Janus skin analyzer examination. This research analysis uses cross sectional observational analytics. Statistical analysis revealed a significant relationship between sleep patterns and premature skin aging with the Asymp value. Sig. (2-tailed) < 0.001. Signs of premature skin aging such as fine wrinkles, large pores, hyperpigmentation begin to appear at the age of 20 years. It can be concluded that insufficient sleep time and quality sleep are factors that influence the occurrence of premature skin aging.
Hubungan Komorbiditas Diabetes Tipe 2 Terhadap Kualitas Hidup Lansia Selama Masa Pandemi Covid-19 Fransiska, Salda; Harliansyah; Widayanti, Etty
Cerdika: Jurnal Ilmiah Indonesia Vol. 3 No. 2 (2023): Cerdika: Jurnal Ilmiah Indonesia
Publisher : Publikasi Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59141/cerdika.v3i02.521

Abstract

Pada Maret 2020, WHO menetapkan sebagai pandemi Covid-19. Pada masa pandemi menjaga kesehatan lansia sangatlah penting terutama yang memiliki penyakit diabetes. Diabetes merupakan salah satu penyakit penyerta komorbiditas yang dapat mempengaruhi kualitas hidup penderita diabetes. Kualitas hidup merupakan kondisi fungsional lansia yang salah satunya dimensi kesehatan fisik. Penelitian ini bertujuan untuk mengetahui hubungan penyakit diabetes terhadap kualitas hidup lansia di Kelurahan Pulo Gadung Jakarta Timur. Penelitian ini merupakan penelitian kuantitatif dengan pendekatan cross sectional. Populasi pada penelitian ini adalah lansia di Keluruhan Pulo Gadung Jakarta Timur. Sampel penelitian adalah seluruh lansia yang memenuhi kriteria inklusi pada penelitian. Analisis data yang digunakan yaitu uji chi-square. Berdasarkan hasil analisis univariat didapatkan kualitas hidup buruk sebanyak 82,9% dan komorbiditas diabetes kategori tinggi didapatkan sebanyak 80%. Hasil analisis bivariat menunjukkan adanya hubungan antara penyakit diabetes terhadap kualitas hidup lansia dengan nilai p-value 0,044 dan nilai OR 4,073. Dapat disimpulkan bahwa lansia dengan komorbiditas penyakit diabetes selama masa pandemi covid-19 dapat menurunkan kualitas hidup. Diharapkan untuk keluarga lansia dapat memperhatikan, membantu, dan terus memberi dukungan kepada orang tuanya (lansia).
Effect of intermittent fasting on fasting blood glucose, sirtuin 1, and total antioxidant capacity in rat models of diabetes mellitus Safitri, Meidiyani; Harliansyah; Wuryanti, Sri
JKKI : Jurnal Kedokteran dan Kesehatan Indonesia JKKI, Vol 15, No 1, (2024)
Publisher : Faculty of Medicine, Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/JKKI.Vol15.Iss1.art5

Abstract

Background: Diabetes mellitus (DM) is a metabolic disease characterized by hyperglycaemia. DM therapy is mainly purposed to control blood glucose levels by adjusting diet and reducing body fat, which can be implemented with calorie restriction (CR) by intermittent fasting (IF), a diet that alternates periods between eating and fasting. Sirtuins, proteins activated by CR, can regulate glucose metabolism, regulate insulin secretion, and protect cells from oxidative stress, so IF is considered to be an opportunity for DM management.Objective: This study is to determine effects of IF on Fasting Blood Glucose (FBG) levels, sirtuin 1 (SIRT1) activity, and total antioxidants (TAOC) in rat models of Wistar with DM.Methods: This experimental study applied a post-test control group design involving 24 Wistar rats which were divided into 4 groups: K1 (rats with DM without IF), K2 (rats with DM treated with metformin 45 mg/kg BW, K3 (rats with DM treated with IF), and K4 (normal rats treated with IF). The diabetes condition were induced with intraperitoneal injection of streptozotocin (STZ). The rats received IF treatment, fasted for 16 hours and ate window open for 8 hours. This treatment was conducted for 14 days. The FBG levels were measured by using a glucometer, while SIRT1 activity and TAOC were measured by using the ELISA method.Results: The statistical analysis using the Kruskal Wallis test for the FBG levels indicated that there was a significant difference among the four groups (p = 0.000). The ANOVA test for SIRT1 activity revealed that there was a significant difference among the four groups (p = 0.001). The Kruskal Wallis test for TAOC pointed out that there was no significant difference among the four groups (p = 0.529).Conclusion: The IF method using a 16:8 regimen reduced the FBG levels and increased the sirtuin 1 activity, but it was not proven to increase the TAOC in the rat models of Wistar with DM.
Co-Authors Amir Mahmud Aprilia, Dhea Dewi Nurul Mustaqimah Etty Widayanti, Etty Fransiska, Salda Hannisa, Muthia Nenden Lilis Aisyah Putriwangi, Awalia syahra Rosalina, Irma Safitri, Meidiyani Sri Wuryanti