Introduction: Chronic Kidney Disease (CKD) is kidney damage characterized by structural and functional abnormalities of the kidneys that last for more than three months. Patients undergo hemodialysis 2 to 3 times per week, with each session lasting 4 to 5 hours. This process causes various psychological problems such as tension, anxiety, stress, and depression, which vary from person to person. In addition, malnutrition is common among patients with chronic kidney disease. Stress levels in patients with chronic kidney disease are a significant issue and can be influenced by various factors during hemodialysis. The purpose of this study was to determine the relationship between the duration of hemodialysis and cognitive function, nutritional status, and stress levels in patients with chronic kidney disease at RSU Haji Medan. Methods: This study employed a descriptive-analytical research method with a cross-sectional design. Data collection took place in December 2024 at RSU Haji Medan. Sampling was conducted using consecutive sampling, with a sample size of 38 participants. Results: There was an association between the duration of hemodialysis and cognitive function in patients with chronic kidney disease at RSU Haji Medan (p=0.001). There was an association between the duration of hemodialysis and nutritional status in patients with chronic kidney disease at RSU Haji Medan (p=0.000). There was an association between the duration of hemodialysis and stress levels in patients with chronic kidney disease at RSU Haji Medan (p=0.001). Conclusion: There is an association between the duration of hemodialysis and cognitive function, nutritional status, and stress in patients with chronic kidney disease at RSU Haji Medan.