Article Per Year (5 Year)
p-Index From 2021 - 2026
0.23
P-Index
This Author published in this journals
All Journal Farmasains : Jurnal Ilmiah Ilmu Kefarmasian
Novita Hasibuan
Bachelor of Pharmacy Study Program, Dirgahayu Samarinda Institute of Health Sciences, Samarinda, East Kalimantan, 75122, Indonesia
Medicine & Pharmacology

Published : 1 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 1 Documents
Search

 1 
Application of Deep Eutectic Solvents to Kleinhovia hospita L.: Total Flavonoid Content and Anti-cholesterol Activity Novita Hasibuan; Nurillahi Febria Leswana; Muh Taufiqurrahman
Farmasains : Jurnal Ilmiah Ilmu Kefarmasian Vol. 13 No. 2 (2026)
Publisher : Universitas Muhammadiyah Prof. DR. HAMKA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22236/farmasains.v13i2.24669

Abstract

Hypercholesterolaemia is a major risk factor for cardiovascular disease. Tahongai (Kleinhovia hospita L.) leaves contain flavonoids with potential cholesterol-lowering activity. This study aimed to determine the total flavonoid content, evaluate the anti-cholesterol activity, and analyse the relationship between both parameters in Kleinhovia hospita L. leaves extracts obtained by Ultrasound-Assisted Extraction (UAE) using Deep Eutectic Solvents (DES) composed of propylene glycol and lactic acid. This experimental study employed DES propylene glycol-lactic acid at three molar ratios (1:1, 1:2, and 2:1). Total flavonoid content was determined using the aluminium chloride colourimetric method with UV–Visible spectrophotometry, while anti-cholesterol activity was evaluated in vitro using the Liebermann–Burchard method, with simvastatin as the positive control. The highest total flavonoid content was found in the DES propylene glycol-lactic acid molar ratio of 2:1, with a value of 679.99 mg QE/g. At 25 µg/mL, the highest cholesterol inhibition was observed at a molar ratio of 2:1  (45.73%), whereas simvastatin showed 89.47% inhibition. Pearson analysis revealed a very strong negative correlation between total flavonoid content and anti-cholesterol activity (r=−0.997; p=0.050). The DES propylene glycol-lactic acid at a molar ratio of 2:1 yielded the highest total flavonoid content and the strongest anti-cholesterol activity.
Co-Authors Nurillahi Febria Leswana Taufiqurrahman, Muh