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All Journal Jurnal Kajian Ilmiah Kesehatan Dan Teknologi (JKIKT)
Vivi Shofia
Politeknik Unggulan Kalimantan
Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health

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AKTIVITAS FRAKSI NONPOLAR DARI EKSTRAK ETANOL AKAR DADANGKAK (Hydrolea spinosa L) TERHADAP PENURUNAN KADAR GLUKOSA DARAH TIKUS JANTAN YANG DIINDUKSI ALOKSAN Muhammad Zaini; Jhudi Bonosari Soediono; Vivi Shofia; Amalia Ajrina
Jurnal Kajian Ilmiah Kesehatan dan Teknologi Vol. 1 No. 2 (2019)
Publisher : Politeknik Unggulan Kalimantan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52674/jkikt.v1i2.7

Abstract

The roots of Dadangkak (Hydrolea spinosa L.) empirically have been used by Kalimantan people to cure diabetes. The purpose of this research is to examine the effect of fractions ratio from ethanol extract. The research started from extraction of the roots of Dadangkak (250 grams) by materation using ethanol. From that extraction yielded 16.62 grams of ethanol extract. Ethanol extract had been fractionated with n-hexane and petroleum ether. The antidiabetic assay using 20 Wistar mice that had been divided into 4 groups : Aquadest 2 ml/200 grams of weight is given to the first group, Glibencalmide 0.45 mg/kg BW is given to the second group, n-hexane fraction 100 mg/kg BW is given to the third group and petroleum eter 100 mg/kg BW is given to the forth group. Before all of groups had been given treatments, the mice had been induced by Aloxan 150 mg/kg BW intraperitoneally. The forth day after being induced, mice also given control and fractions treatments for 7 days perorally. The measurement of blood glucose level had been done at the first, forth, and twelfth day after being induced using Gluco-DR. The blood glucose level had been tested by SPSS with 95% confidence level. The result of this research showed the average of blood glucose level by the n-hexane fraction is 189,8 ± 13,59 mg/dL and petroleum ether is 437,6 ± 8,98 mg/dL. n-hexane fraction could decrease the blood glucose level of mice significantly (sig<0.05) compared to the control group. On the other side, the giving of petroleum ether fraction is not showing the decrease of blood glucose level significantly (sig>0.05).
SKRINING FITOKIMIA EKSTRAK CARICA PAPAYA RADIX, PIPER ORNATUM FOLIUM DAN NEPHELIUM LAPPACEUM SEMEN ASAL KALIMANTAN SELATAN Muhammad Zaini; Vivi Shofia
Jurnal Kajian Ilmiah Kesehatan dan Teknologi Vol. 2 No. 1 (2020)
Publisher : Politeknik Unggulan Kalimantan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52674/jkikt.v2i1.30

Abstract

Diabetes Mellitus was a disease with a high prevalence and was ranked in the top 10 in the world including in Indonesia. The big problem facing the health world today was Diabetes Mellitus cannot be completely cured with conventional antihyperglycemic drugs. Research needs to be done in terms of tracing the potential of natural materials commonly used by Kalimantan people based on phytochemical screening of some plants that are empirically used as antidiabetic namely Carica papaya radix (CPR), Nephelium lappaceum semen (NLS) and Piper ornatum folium (POF). Medicinal plants obtained were extracted maceration and identified groups of compounds and their chromatographic profiles. These research activities included: 1) Plant sample collection, 2) Making test simplicia, 3) Making plant ethanol extract, 4) Qualitative test of plant chemical content, and 5) Thin layer chromatography identification. The results of the study were selected and tested on 3 extracts namely Carica papaya radix, Nephelium lappaceum semen and Piper ornatum folium. Carica papaya radix extract was thought to contain alkaloid compounds (Rf: 0.53), saponins (Rf: 0.93), flavonoids (Rf: 0.38; 0.75) and tannins (Rf: 0.52; 0.88) . Piper ornatum folium extract is thought to contain saponin compounds (Rf: 0.89), steroids (Rf: 0.20; 0.42) and tannins (Rf: 0.52; 0.71; 0.85). Nephelium lappaceum semen extract showed positive results on the presence of alkaloid compounds (Rf: 0.65; 0.82), flavonoids (Rf: 0.83) and tannins (Rf: 0.79; 0.92).
Co-Authors Amalia Ajrina Jhudi Bonosari Soediono Muhammad Zaini