Article Per Year (5 Year)
p-Index From 2021 - 2026
0.408
P-Index
This Author published in this journals
All Journal Jurnal Penelitian Farmasi dan Herbal
Putri Anggita
Fakultas Farmasi, Institut Kesehatan Deli Husada Deli Tua
Medicine & Pharmacology

Published : 2 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 2 Documents
Search

 1 
PENGARUH VARIASI pH DAPAR FOSFAT TERHADAP PROFIL ABSORPSI PARASETAMOL MENGGUNAKAN MODEL EVERTED SAC DUODENUM KELINCI SECARA EKS VIVO Gratia Apulina Cindylawsa Purba; Putri Anggita; Delisma Marsauli Simorangkir; Ageng Azhar Amar
Jurnal Penelitian Farmasi & Herbal Vol. 9 No. 1 (2026): Jurnal Penelitian Farmasi dan Herbal
Publisher : Fakultas Farmasi Institut Kesehatan DELI HUSADA Deli Tua

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36656/0rjv0w60

Abstract

Paracetamol is the most widely used non-opioid analgesic-antipyretic, yet its oral bioavailability (70–90%) is influenced by the physiological conditions of the gastrointestinal tract, including intraluminal pH. This study aimed to analyze the effect of phosphate buffer pH variation (pH 5.8 and 7.4) on the absorption profile of paracetamol using an ex vivo rabbit everted duodenal sac model. Paracetamol concentrations in the serosal fluid were measured serially at 0, 5, 10, 20, 30, 40, 50, and 60 minutes using UV-Vis spectrophotometry at an analytical wavelength of 243 nm. The calibration curve at pH 5.8 yielded the linear regression equation y = 0.108x – 0.009 (r = 0.998), while at pH 7.4 the equation y = 0.045x + 0.019 (r = 0.999) was obtained, indicating high linearity under both conditions. Paracetamol concentration in the serosal compartment increased progressively up to around minutes 20–40 under both pH conditions, with a higher concentration profile observed at pH 7.4 compared to pH 5.8, consistent with the increased non-ionized fraction of paracetamol approaching the physiological duodenal condition. Concentration fluctuations during the final minutes of incubation are presumed to relate to the serial dilution effect from sampling replacement and declining tissue viability over time. This study demonstrates that intraluminal pH plays an important role in determining the rate and extent of paracetamol absorption in the rabbit everted duodenal sac model, providing a basis for the formulation of pH-sensitive oral dosage forms
FORMULASI SEDIAAN KAPSUL DAN UJI EFEKTIFITAS EKSTRAK ETANOL KOMBINASI DAUN KECOMBRANG (Etlungera elatior) DAN DAUN PEPAYA (Carica papaya L) SEBAGAI ANTIHIPERLIPIDEMIA PADA TIKUS PUTIH JANTAN (Rattus norvegicus) PUTRI ANGGITA; Delisma Marsauli Simorangkir; Gratia Apulina Cindylawsa Purba
Jurnal Penelitian Farmasi & Herbal Vol. 9 No. 1 (2026): Jurnal Penelitian Farmasi dan Herbal
Publisher : Fakultas Farmasi Institut Kesehatan DELI HUSADA Deli Tua

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36656/cd0jkk86

Abstract

Hyperlipidemia is a lipid metabolism disorder which is characterized by an increase in total cholesterol levels in the blood which can be treated with traditional medicine from plants. One example of plants that can be used are kecombrang leaves and papaya leaves which contain flavonoids that work by reducing HMG-CoA reductase levels which will have the effect of reducing cholesterol levels in the body. Saponins lower triglyceride levels in the blood, by influencing the formation of fatty acids in the liver.Tannins prevent the oxidation of cholesterol. This study was conducted to determine the effect of the ethanol extract of the combination of kecombrang leaves and papaya leaves in reducing blood hyperlipidemia levels compared to simvastatin. An experimental study to examine hyperlipidemia levels using the CHOD-PAP method used 21 rats induced with a high-fat diet and divided into 7 groups. namely the negative group (CMC Na 0.5%), the positive group (simvastatin), the single kecombrang extract group 140mg/kgBW, the papaya single extract group 120mg/kgBW, the combined extract 70mg/kgBW and 60mg/kgBW, the combined extract 140mg/kgBW and 120mg/kgBW, and a combination extract of 210mg/kgBW and 180mg/kgBW. The data were analyzed using the one way ANOVA method. The results showed that the most effective treatment was simvastatin and a combination of 210mg/kgBW and 180mg/kgBW. The results of group data analysis had an effect on cholesterol reduction because the sig value was > 0.05. Based on ANOVA analysis, one of the seven most effective treatments was simvastatin, f5, f4, f3, f2 f1 and cmc na 0.5%
Co-Authors Ageng Azhar Amar Delisma Marsauli Simorangkir Delisma Marsauli Simorangkir Gratia Apulina Cindylawsa Purba