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Delisma Marsauli Simorangkir
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Medicine & Pharmacology

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FORMULASI EKSTRAK ETANOL BUAH PARE DAN DAUN PEPAYA SEBAGAI LOSION REPELAN Aedes aegypti Gratia Apulina Cindylawsa Purba; Delisma Marsauli Simorangkir; Tio Ranti Sari Br Sembiring; Putri Anggita
Jurnal Penelitian Farmasi & Herbal Vol. 8 No. 2 (2026): Jurnal Penelitian Farmasi dan Herbal
Publisher : Fakultas Farmasi Institut Kesehatan DELI HUSADA Deli Tua

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36656/jpfh.v8i2.2949

Abstract

Dengue Hemorrhagic Fever (DHF) is a disease caused by the dengue virus from the genus Flavivirus and the family Flaviviridae, transmitted through the bites of Aedes aegypti and Aedes albopictus. One preventive measure can be achieved by using mosquito repellent lotion as a protective topical preparation. Bitter melon and papaya leaves contain flavonoids and antioxidants that have potential as natural repellent agents. This study aimed to evaluate the effectiveness of lotion formulations containing bitter melon and papaya leaf extracts at concentrations of 0%, 2%, 4%, and 6%. The research method included preparing lotion formulations based on an oil-in-water emulsion, followed by physical quality testing according to SNI 16-4399-1996, including assessments of homogeneity, emulsion type, two-week stability, and skin irritation. Repellent effectiveness was tested by observing the number of mosquitoes that died after contacting skin treated with the lotion. The results show that all formulations meet the physical quality requirements, are homogeneous, stable, possess an oil-in-water emulsion type, and do not cause skin irritation. The extracts increase mosquito repellency, as indicated by the greater number of dead mosquitoes with higher extract concentrations. The 6% formulation is the most effective concentration as a repellent or insecticidal agent against Aedes aegypti.
FORMULASI SEDIAAN KAPSUL DAN UJI EFEKTIFITAS EKSTRAK ETANOL KOMBINASI DAUN KECOMBRANG (Etlungera elatior) DAN DAUN PEPAYA (Carica papaya L) SEBAGAI ANTIHIPERLIPIDEMIA PADA TIKUS PUTIH JANTAN (Rattus norvegicus) PUTRI ANGGITA; Delisma Marsauli Simorangkir; Gratia Apulina Cindylawsa Purba
Jurnal Penelitian Farmasi & Herbal Vol. 9 No. 1 (2026): Jurnal Penelitian Farmasi dan Herbal
Publisher : Fakultas Farmasi Institut Kesehatan DELI HUSADA Deli Tua

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36656/cd0jkk86

Abstract

Hyperlipidemia is a lipid metabolism disorder which is characterized by an increase in total cholesterol levels in the blood which can be treated with traditional medicine from plants. One example of plants that can be used are kecombrang leaves and papaya leaves which contain flavonoids that work by reducing HMG-CoA reductase levels which will have the effect of reducing cholesterol levels in the body. Saponins lower triglyceride levels in the blood, by influencing the formation of fatty acids in the liver.Tannins prevent the oxidation of cholesterol. This study was conducted to determine the effect of the ethanol extract of the combination of kecombrang leaves and papaya leaves in reducing blood hyperlipidemia levels compared to simvastatin. An experimental study to examine hyperlipidemia levels using the CHOD-PAP method used 21 rats induced with a high-fat diet and divided into 7 groups. namely the negative group (CMC Na 0.5%), the positive group (simvastatin), the single kecombrang extract group 140mg/kgBW, the papaya single extract group 120mg/kgBW, the combined extract 70mg/kgBW and 60mg/kgBW, the combined extract 140mg/kgBW and 120mg/kgBW, and a combination extract of 210mg/kgBW and 180mg/kgBW. The data were analyzed using the one way ANOVA method. The results showed that the most effective treatment was simvastatin and a combination of 210mg/kgBW and 180mg/kgBW. The results of group data analysis had an effect on cholesterol reduction because the sig value was > 0.05. Based on ANOVA analysis, one of the seven most effective treatments was simvastatin, f5, f4, f3, f2 f1 and cmc na 0.5%
Co-Authors Gratia Apulina Cindylawsa Purba Gratia Apulina Cindylawsa Purba Putri Anggita Putri Anggita SEMBIRING, TIO RANTI SARI