Three-month injectable contraception is one of the most widely used contraceptive methods because it is practical, effective, and requires relatively infrequent injections. However, prolonged use of injectable contraception may cause side effects, including weight gain. This study aimed to determine the relationship between the duration of three-month injectable contraceptive use and weight gain among family planning acceptors at the Independent Midwifery Practice of Sherli Deviana. This study employed a quantitative analytic design with a cross-sectional approach. The study population consisted of all three-month injectable contraceptive acceptors, totaling 59 participants. A total sampling technique was applied, resulting in a sample of 59 respondents. Data were collected using a structured questionnaire and digital weighing scales. The results showed that the majority of respondents were over 35 years old (33 respondents; 55.9%), had completed junior high school and senior high school education (21 respondents each; 35.6%), were housewives (25 respondents; 42.4%), had used three-month injectable contraception for more than two years (44 respondents; 74.6%), and had experienced weight gain (43 respondents; 72.9%). Bivariate analysis revealed a statistically significant relationship between the duration of three-month injectable contraceptive use and weight gain among contraceptive acceptors at PMB Sherli Deviana, with a p-value of 0.016. These findings indicate that the longer the duration of three-month injectable contraceptive use, the greater the likelihood of weight gain among contraceptive acceptors.