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All Journal Indonesian Journal of Cancer Chemoprevention Jurnal Permata Indonesia Jurnal Pengabdian Masyarakat Permata Indonesia
Nugraheni, Nadzifa
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Biochemistry, Genetics & Molecular Biology Health Professions Medicine & Pharmacology Nursing Public Health

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Chemopreventive Properties Curcuma heyneana Rhizome Ethanolic Extract on Hepatocellular Carcinoma Cells, JHH-4 Santoso, Christopher Filando; Rahmawati, Desty Restia; Nugraheni, Nadzifa; Adisusilo, Midori Rahmadhany Putri; Maharani, Dini; Hermawan, Adam; Meiyanto, Edy
Indonesian Journal of Cancer Chemoprevention Vol 15, No 1 (2024)
Publisher : Indonesian Society for Cancer Chemoprevention

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14499/indonesianjcanchemoprev15iss1pp40-49

Abstract

Hepatocellular carcinoma is the most common type of liver cancer. Curcuminoids are natural polyphenol compounds abundant in Curcuma heyneana ethanolic extract (CHE) and are known to inhibit breast and cervical cancer cell proliferation. Based on previous research, curcuminoid compounds have been studied to inhibit the growth of the liver cancer cell model, HepG2. This study aims to examine the potential of CHE as a chemopreventive agent in liver cancer using JHH-4 cell as a model. CHE was obtained by maceration method using ethanol which was then identified for its phytochemical profile using thin layer chromatography (TLC). Then TLC results were quantified to calculate the levels of compounds present in the CHE based on spot intensity with ImageJ software. 2,2-Diphenyl-1-picrylhydrazyl (DPPH) antioxidant assay was conducted to determine the radical scavenging activity of CHE. Cytotoxic activity of CHE on JHH-4 liver cancer cells was tested by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. Extraction produces a yield of 10.2 %w/w. CHE contains 4.52 %w/w curcuminoid compound consisting of 0.49 %w/w curcumin, 3.21 %w/w demethoxycurcumin, and 0.82% w/w bisdemethoxycurcumin. CHE exhibited antioxidant activity with an IC50 value of 378.96 μg/mL, meanwhile ascorbic acid as a positive control has an IC50 value of 8.49 μg/mL. Cytotoxic activity of CHE on JHH-4 cells is characterized by an IC50 value of 16.62 μg/mL which is classified as having strong cytotoxic activity. This study concluded that CHE has the potential to be developed as a chemopreventive agent in liver cancer.Keywords: liver cancer, hepatocelullar carcinoma, Chemopreventive, antioxidant,Curcuma heyneana.
Analog Curcumin, Pentagamavunon-0 (PGV-0), Induces Senescence and Increases Cytotoxic Effect of Doxorubicin on HCC 1954 Cells Angraini, Sonia Meta; Nugraheni, Nadzifa; Meiyanto, Edy; Hermawan, Adam
Indonesian Journal of Cancer Chemoprevention Vol 10, No 3 (2019)
Publisher : Indonesian Society for Cancer Chemoprevention

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14499/indonesianjcanchemoprev10iss3pp114-121

Abstract

Senescence defined as an irreversible cell cycle arrest. Senescence can inhibit cancer growth and suppress the progression of cancer. Some anticancer compounds are known to have the potential to induce senescence. Senescence defence against tumor development by preventing proliferation of cells with DNA damage. The study aimed to determine the cytotoxic effects and senescence induction of Pentagamavunon-0 (PGV-0) on Human Epidermal Growth Factor Receptor 2-positive (HER2-positive) breast cancer cells, HCC 1954. Cytotoxic tests carried out with 3- (4.5-dimethylthiazzol-2yl) -2.5-tidiphenyltetrazolium (MTT) assay showed that PGV-0 exhibited a strong cytotoxic effect with a the half maximal inhibitory concentration (IC50) value of 39 μM. Treatment with IC50 in sub-doses combined with doxorubicin showed cytotoxic enhancement effects. The senescence assay using SA-β-Galactosidase showed that the PGV-0 in a single treatment was able to induce senescence with a percentage of cell senescent of 15%. The combination treatment of PGV-0 at the half dose of IC50 with doxorubicin 100 nM was able to induce senescence with the percentage of senescent cells of 25%. Moreover, PGV-0 also increased intracellular reactive oxygen species (ROS). The results of this study indicate that PGV-0 exhibits cytotoxic effect, increases cytotoxic effect of doxorubicin and induces senescence that may correlate to the increasing of intracellular ROS in 1954 HCC cells.Keywords: Pentagamavunon (PGV-0), HCC 1954, Cytotoxic, Senescence
Edukasi Swamedikasi Rasional melalui Gerakan Masyarakat Cerdas Menggunakan Obat (GeMa CerMat) pada Komunitas Keluarga Alumni Pondok Pesantren Inayatullah di Sleman Dilalah, Idlohatud; Christiandari, Hanita; Hernawan, Jarot Yogi; Suprasetya, Edy; Laila, Wahyu Kumil; Nugraheni, Nadzifa
Jurnal Pengabdian Masyarakat Permata Indonesia Vol 5 No 2 (2025): Volume 5, Nomor 2, Oktober 2025
Publisher : Permata Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59737/jpmpi.v5i2.358

Abstract

Self-medication refers to an individual’s effort to treat their own health complaints based on symptoms they experience. This practice commonly involves purchasing over-the-counter drugs, using leftover prescribed medicines, or taking medications recommended by family members, friends, or the media without medical supervision. Such self-treatment carries the risk of irrational drug use; therefore, education is essential to enhance public literacy regarding the proper use of medicines. The Inayatullah Islamic Boarding School Alumni Family Community consists of former students and their families, most of whom are in the 25–35 age range and have recently started families. This community service program aims to improve participants’ knowledge and attitudes toward self-medication through a community-based educational approach. The activity was implemented through the Smart Community Movement for the Rational Use of Medicines (GeMa CerMat), conducted in the form of interactive lectures and discussions during a regular monthly gathering at one of the alumni’s residences in Dukuh Nandan, Sariharjo Village, Ngaglik District, Sleman Regency. Participants actively engaged in discussions about appropriate and rational self-medication practices. It is expected that this educational initiative will enhance the community’s understanding of responsible self-medication, enabling them to make wiser decisions in treating minor health problems and to prevent irrational drug use.
Pengembangan Sabun Padat Transparan Berbasis Ekstrak Rimpang Bangle (Zingiber cassumunar Roxb.): Formulasi dan Uji Mutu Fisik Hernawan, Jarot Yogi; Laila, Wahyu Kumil; Wahyu Ika Lestari, Nur; Dilalah, Idlohatud; Christiandari, Hanita; Nugraheni, Nadzifa
Jurnal Permata Indonesia Vol 16 No 2 (2025): Volume 16 Nomor 2, November 2025
Publisher : Politeknik Kesehatan Permata Indonesia Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59737/jpi.v16i2.372

Abstract

Rimpang bangle (Zingiber cassumunar Roxb.) merupakan bahan alam yang memiliki efek antibakteri dan antioksidan untuk kulit. Penelitian ini bertujuan mengembangkan sabun padat transparan berbasis ekstrak rimpang bangle serta mengevaluasi mutu fisiknya. Ekstrak bangle diperoleh melalui metode maserasi menggunakan etanol 96% dengan rendemen 10,50%. Ekstrak diformulasikan ke dalam empat formula sabun (F0–F3) dengan konsentrasi 0%, 3%, 6%, dan 9%. Evaluasi mutu fisik meliputi uji organoleptis, homogenitas, tinggi busa, pH, dan kadar alkali bebas. Hasil menunjukkan bahwa semua formula memiliki bentuk padat oval, sementara penambahan ekstrak memengaruhi warna dari putih transparan (F0) menjadi oranye hingga oranye kecoklatan (F1–F3), disertai munculnya aroma khas bangle. Seluruh sediaan homogen tanpa terlihat adanya gumpalan. Tinggi busa menurun seiring peningkatan konsentrasi ekstrak, dari 115 mm (F0) menjadi 98,3 mm (F3), namun tetap memenuhi persyaratan SNI (13–220 mm). Nilai pH berada pada rentang 9,45–10,65 dan seluruhnya sesuai standar SNI (9–11). Kadar alkali bebas meningkat seiring peningkatan ekstrak, tetapi tetap berada di bawah batas SNI (<0,1%), sehingga aman digunakan. Secara keseluruhan, penambahan ekstrak bangle memengaruhi warna, aroma, tinggi busa, pH, dan kadar alkali bebas, namun seluruh formula tetap memenuhi standar mutu fisik, sehingga ekstrak bangle berpotensi sebagai bahan aktif alami dalam formulasi sabun transparan.
Co-Authors Adam Hermawan Adisusilo, Midori Rahmadhany Putri Angraini, Sonia Meta Christiandari, Hanita Dilalah, Idlohatud Dini Maharani Edi Suprasetya Edy Meiyanto Hernawan, Jarot Yogi Laila, Wahyu Kumil Rahmawati, Desty Restia Santoso, Christopher Filando Wahyu Ika Lestari, Nur